Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors

Objective The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs). Study design Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 a...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-09, Vol.108 (3), p.417-424
Main Authors: Souza Freitas, Valéria, DDS, MSc, Ferreira de Araújo, Cristina Ruan, DDS, MSc, Alves, Pollianna Muniz, DDS, MSc, de Souza, Lélia Batista, DDS, MSc, PhD, Galvão, Hébel Cavalcanti, DDS, MSc, PhD, de Almeida Freitas, Roseana, DDS, MSc, PhD
Format: Article
Language:English
Subjects:
Ameloblastoma - enzymology
Biological and medical sciences
Connective Tissue - enzymology
Dentistry
Endothelial Cells - enzymology
Epithelial Cells - enzymology
Epithelium - enzymology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Fibroblasts - enzymology
Humans
Immunohistochemistry
Matrix Metalloproteinase 7 - analysis
Matrix Metalloproteinases, Secreted - analysis
Medical sciences
Odontogenic Tumors - enzymology
Otorhinolaryngology. Stomatology
Surgery
Tumors
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Summary:Objective The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs). Study design Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 and -26 in the epithelium and stroma. Results There was no statistically significant difference in MMP-7 and -26 expression between the epithelium of ameloblastomas ( P = .50) and AOTs ( P = .90). Stromal staining for MMP-7 was evident in all cases. For MMP-26, stromal staining was observed in 65% of ameloblastomas and 50% of AOTs, and this difference was not statistically significant ( P = .69). Conclusion The marked expression of these matrilysins suggests their role in the process of tissue remodeling and growth in the studied tumors, but it does not relate to the their distinct patterns of aggressiveness.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.03.035