Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia

Hyperlipidaemia is a clinical and metabolic disorder characterized by abnormal elevation in the major circulatory lipid and lipoprotein levels accounting for approximately 56% cases of cardiovascular diseases worldwide and causes about 4.4 million deaths annually. Based on World Health Organization...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2010-07, Vol.130 (2), p.307-314
Main Authors: Adeneye, Adejuwon Adewale, Adeyemi, Olufunmilayo Olaide, Agbaje, Esther Oluwatoyin
Format: Article
Language:English
Subjects:
Administration, Oral
animal models
Animals
Anti-Obesity Agents - administration & dosage
Anti-Obesity Agents - pharmacology
Anti-obesity plant
anticholesteremic agents
Antihyperlipidaemic effect
antilipemic agents
Apocynaceae
aqueous solutions
atherogenesis
Biological and medical sciences
cardioprotective effect
Cardioprotective potential
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
cholesteremic effect
cholesterol
Disease Models, Animal
dose response
Dose-Response Relationship, Drug
Feeding Behavior - drug effects
Female
General pharmacology
Hunteria
Hunteria umbellata
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hyperlipidaemic models
hyperlipidemia
Hyperlipidemias - blood
Hyperlipidemias - chemically induced
Hyperlipidemias - physiopathology
Hyperlipidemias - prevention & control
Hypolipidemic Agents - administration & dosage
Hypolipidemic Agents - pharmacology
intestinal absorption
lipid metabolism
Lipids - blood
Liver - drug effects
Liver - pathology
Male
Medical sciences
medicinal plants
obesity
Olive Oil
oral administration
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Oils
Polyethylene Glycols
Rats
Rats, Wistar
seed extracts
Seeds
Simvastatin - pharmacology
Time Factors
Weight Gain - drug effects
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Summary:Hyperlipidaemia is a clinical and metabolic disorder characterized by abnormal elevation in the major circulatory lipid and lipoprotein levels accounting for approximately 56% cases of cardiovascular diseases worldwide and causes about 4.4 million deaths annually. Based on World Health Organization recommendations that hypolipidaemic and hypocholesterolaemic agents of plant origin used in traditional medicine should be further evaluated to complement the synthetic antihyperlipidaemic drugs. The current study investigates the anti-obesity and antihyperlipidaemic effects of 50–200 mg/kg of the cold water extract of the dried seeds of Hunteria umbellata (K. Schum.) Hallier f. (Apocynaceae) in three different in vivo experimental models of obesity and hyperlipidaemia. The voucher specimen of the plant is as provided in Fig. 1. In Nigerian folk medicine, water infusion of the dried seeds of Hunteria umbellata (K. Schum.) Hallier f. has a reputation for the local management of obesity and hyperlipidaemia. The present study is aimed at evaluating the anti-obesity and antihyperlipidaemic activities as well as the underlying mechanisms of action of the aqueous seed extract of Hunteria umbellata ( HU) in normal, triton-induced, and olive oil-induced hyperlipidaemic rats. Normal and olive oil-induced hyperlipidaemic, and triton-induced hyperlipidaemic rats were pre-treated with single, daily oral administration of 10 ml/kg of distilled water, 20 mg/kg of simvastatin, 50 mg/kg, 100 mg/kg and 200 mg/kg of HU in 10 ml/kg of distilled water for 28 days and 24 h. The effects of these drugs on % body weight change, feeding pattern, serum lipids, coronary artery risk index (CRI) and atherogenic index (AI) and Lee's index (LI) were investigated. Oral pre-treatment with simvastatin and graded oral doses of HU significantly ( p < 0.05) reduced the weight gain pattern and caused dose related ( p < 0.05, p < 0.01 and p < 0.001) reductions in the serum lipids, CRI, AI and LI. Also, HU pre-treatment significantly improved triton-induced hepatic histological lesions. Results of this study showed that HU has both anti-obesity and antihyperlipidaemic effects which may partly be mediated via inhibition of intestinal lipid absorption and de novo biosynthesis of cholesterol. Thus, the results justify the ethnopharmacological use of the extract in the management of obesity and hyperlipidaemia.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2010.05.009