The influence of early postnatal nutrition on retinopathy of prematurity in extremely low birth weight infants

Abstract Background Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm infants. Human milk may provide a protective effect for ROP; however, beneficial effects of human milk preclude randomized trials. Therefore, we conducted a retrospective analysis comparing e...

Full description

Saved in:

Bibliographic Details
Published in:	Early human development 2010-06, Vol.86 (6), p.391-396
Main Authors:	Porcelli, Peter J, Weaver, R. Grey
Format:	Article
Language:	eng
Subjects:	Advanced Basic Science Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Enteral nutrition Fundamental and applied biological sciences. Psychology Human milk Humans Infant, Newborn Infant, Very Low Birth Weight Lung Diseases - prevention & control Milk, Human Neonatal and Perinatal Medicine Nutrition Assessment Parenteral Nutrition Preterm infant Retinopathy of prematurity Retinopathy of Prematurity - prevention & control Retinopathy of Prematurity - surgery Retrospective Studies Vitamin Vitamin A - therapeutic use Vitamin E - therapeutic use
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Background Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm infants. Human milk may provide a protective effect for ROP; however, beneficial effects of human milk preclude randomized trials. Therefore, we conducted a retrospective analysis comparing early postnatal nutrition with ROP development. Objective Evaluate relationship between early postnatal nutriture and ROP surgery. Design/methods Nutrition data was collected for inborn AGA infants, BW 700–1000 g. ROP surgery was the primary outcome variable. A single pediatric ophthalmologist supervised examinations. All infants received triweekly IM vitamin A as chronic lung disease prophylaxis (Tyson: NEJM, 1999). Results BW and gestational age were 867 ± 85 g and 26.3 ± 1.2 weeks ( n = 77, mean ± 1SD). ROP surgery infants( n = 11) received more parenteral nutrition, 1648 mL, and less human milk, 13.8 mL/kg-day, and vitamin E, 1.4 mg/kg-day, during the second postnatal week. Human milk was a negative predictor for ROP surgery, odds ratio = 0.94. Both groups met vitamin A recommendations; however, 74% was administered via IM injections. Neither group met vitamin E recommendations. Conclusions Human milk feeding, parenteral nutrition volume and vitamin E intake were predictors for ROP surgery. IM vitamin A injections provided the majority of vitamin A; vitamin E administration was insufficient. Improving human milk feeding rates and vitamin dosing options may affect ROP surgery rates.
ISSN:	0378-3782 1872-6232