Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation

The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defect...

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Bibliographic Details
Published in:Phytotherapy research 2010-06, Vol.24 (S2), p.S155-S160
Main Authors: Wong, R.W.K, Rabie, A.B.M
Format: Article
Language:English
Subjects:
Animals
bone graft
Bone grafts
Bone growth
Bone matrix
Buguzhi extract
Collagen
Collagen - pharmacology
Drugs, Chinese Herbal - pharmacology
Fruit - chemistry
Fruits
Image processing
Osteogenesis
Osteogenesis - drug effects
parietal bone
Parietal Bone - drug effects
Parietal Bone - pathology
Phytotherapy
Plant Extracts - pharmacology
Psoralea
Psoralea - chemistry
Rabbits
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Summary:The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.3049