Eber- and LMP-1-expressing pulmonary lymphoepithelioma-like carcinoma in a caucasian patient

Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a rare tumor that preferentially affects Asian patients, with only 15 cases described in Caucasians to date. Epstein-Barr virus (EBV) infection is present in most lung LELCs in Asians, but it has never been shown in Caucasians. EBV small...

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Bibliographic Details
Published in:Human pathology 2003-06, Vol.34 (6), p.623-625
Main Authors: Morbini, Patrizia, Riboni, Roberta, Tomaselli, Stefano, Rossi, Albino, Magrini, Umberto
Format: Article
Language:English
Subjects:
Adult
Airway management
Antigens, Viral - analysis
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Biomarkers, Tumor
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - therapy
Carcinoma, Squamous Cell - virology
Caucasian
Cell Nucleus - metabolism
Cell Nucleus - pathology
Cell Nucleus - virology
Chemotherapy
Combined Modality Therapy
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - metabolism
Epstein-Barr Virus Infections - pathology
Epstein-Barr virus small nuclear RNA
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - immunology
Herpesvirus 4, Human - isolation & purification
Humans
Immunohistochemistry
latent membrane protein 1
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Lung Neoplasms - virology
Lymphocytes
Male
Medical imaging
Medical sciences
Neoplasm Staging
Palliative Care
Pneumology
Pulmonary arteries
pulmonary lymphoepithelioma-like carcinoma
Radiation therapy
Radiotherapy
Ribosomal Proteins
RNA-Binding Proteins - metabolism
Treatment Outcome
Tumors
Tumors of the respiratory system and mediastinum
Viral Matrix Proteins - metabolism
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Summary:Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a rare tumor that preferentially affects Asian patients, with only 15 cases described in Caucasians to date. Epstein-Barr virus (EBV) infection is present in most lung LELCs in Asians, but it has never been shown in Caucasians. EBV small nuclear RNA and latent membrane protein-1 were identified in the neoplastic cells of primary LELC of the lung diagnosed by endobronchial biopsy in a 25-year-old Italian male. Despite advanced locoregional disease, with neoplastic infiltration of the main right bronchus, the carina, and the pulmonary artery, which prevented surgical resection, partial response and 1-year symptom-free follow-up were achieved after combined chemotherapy and radiotherapy.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(03)00081-9