Red blood cell distribution width predicts long-term outcome regardless of anaemia status in acute heart failure patients

Aims To study the long-term prognostic value of red blood cell distribution width (RDW) in patients hospitalized with acute heart failure (AHF) and to compare the value of this measurement with haemoglobin levels and anaemia status. Methods and results During a 2-year period, we studied 628 consecut...

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Bibliographic Details
Published in:European journal of heart failure 2009-09, Vol.11 (9), p.840-846
Main Authors: Pascual-Figal, Domingo A., Bonaque, Juan C., Redondo, Belen, Caro, Cesar, Manzano-Fernandez, Sergio, Sánchez-Mas, Jesús, Garrido, Iris P., Valdes, Mariano
Format: Article
Language:English
Subjects:
Acute Disease
Acute heart failure
Anaemia
Anemia
Confidence Intervals
Erythrocytes
Female
Health Status
Heart Failure - diagnostic imaging
Heart Failure - mortality
Heart Failure - physiopathology
Heart Rate
Humans
Kaplan-Meier Estimate
Male
Models, Statistical
Multivariate Analysis
Prognosis
Proportional Hazards Models
Red cell
Risk Assessment
Risk Factors
Statistics, Nonparametric
Time Factors
Treatment Outcome
Ultrasonography
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Summary:Aims To study the long-term prognostic value of red blood cell distribution width (RDW) in patients hospitalized with acute heart failure (AHF) and to compare the value of this measurement with haemoglobin levels and anaemia status. Methods and results During a 2-year period, we studied 628 consecutive patients (aged 71 years [interquartile range, IQR: 61-77], 68% male) hospitalized with AHF. Demographic, clinical, echocardiographic, and laboratory characteristics were registered at discharge and patients were closely followed-up for 38.1 months [16.5-49.1]. Median RDW was 14.4% [13.5-15.5] and was higher among decedents (15.0% [13.8-16.1] vs. 14.2 [13.3-15.3], P < 0.001). After adjustment for other prognostic factors in a multivariable Cox proportional-hazards model, RDW remained a significant predictor (P = 0.004, HR 1.072, 95% CI 1.023-1.124); whereas, haemoglobin or anaemia status did not add prognostic information. RDW levels above the median were associated with a significantly lower survival rate on long-term follow-up (log rank
ISSN:1388-9842
1879-0844
DOI:10.1093/eurjhf/hfp109