Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates

Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2009-09, Vol.17 (17), p.6292-6300
Main Authors: LaBeaume, Paul, Wager, Krista, Falcone, Danielle, Li, Jane, Torchilin, Vladimir, Castro, Curtis, Holewa, Coleen, Kallmerten, Amy E., Jones, Graham B.
Format: Article
Language:English
Subjects:
Antibodies - chemistry
Antibodies - immunology
Antibody conjugate
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Bioconjugate
Biological and medical sciences
Chemistry
Enediyne
Enediynes - chemical synthesis
Enediynes - chemistry
Enediynes - pharmacology
Exact sciences and technology
Gold - chemistry
Medical sciences
Metal Nanoparticles - chemistry
Nanoparticles
Noncondensed benzenic compounds
Organic chemistry
PDT
Photo-Bergman
Photoradiation therapy and photosensitizing agent
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Polyethylene Glycols - chemistry
Preparations and properties
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced. Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2009.07.059