Solitary fibrous tumor of the head and neck

Objective The aim of this study was to review the reported cases of solitary fibrous tumor (SFT) in the head and neck and to evaluate this tumor regarding histologic features, treatment, and recurrence. SFT has been described in many extrapleural sites, including the head and neck. Uniform overexpre...

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Published in:	Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010-07, Vol.110 (1), p.79-84
Main Authors:	Cox, Darren P., DDS, MBA, Daniels, Troy, DDS, MS, Jordan, Richard C.K., DDS, PhD, FRCPath
Format:	Article
Language:	eng
Subjects:	Age Factors Biological and medical sciences Dentistry Female Head and Neck Neoplasms - pathology Humans Male Medical sciences Neoplasm Recurrence, Local - pathology Otorhinolaryngology. Stomatology Sex Factors Solitary Fibrous Tumors - pathology Surgery
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Summary:	Objective The aim of this study was to review the reported cases of solitary fibrous tumor (SFT) in the head and neck and to evaluate this tumor regarding histologic features, treatment, and recurrence. SFT has been described in many extrapleural sites, including the head and neck. Uniform overexpression of CD34 differentiates SFT from other spindle cell neoplasms. SFT is a slow-growing neoplasm that can be successfully treated by complete excision. A rare malignant counterpart has also been described. Study design In this case series and review of published cases from English-language journals in the National Library of Medicine, we reviewed 142 cases of SFT reported in English-language literature and add 11 new cases. We compared the features reported in the previous publications of SFT from the head and neck with our series, including cases described as malignant or atypical SFT. Results Four out of 9 cases with positive margins recurred, whereas only 1 out of 10 cases with atypical or malignant features recurred. Conclusions An important finding in SFT of the head and neck is that recurrence appears more related to incomplete excision than to microscopic grade.
ISSN:	1079-2104 1528-395X