2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Compound 47 was found to be a potent inhibitor of CETP and had an IC 50 of 28 nM. A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure–activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters 2010, Vol.20 (1), p.346-349
Main Authors:	Smith, Cameron J., Ali, Amjad, Chen, Liya, Hammond, Milton L., Anderson, Matt S., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Sparrow, Carl P., Wright, Samuel D., Sinclair, Peter J.
Format:	Article
Language:	eng
Subjects:	Acetanilides - chemical synthesis Acetanilides - chemistry Acetanilides - pharmacokinetics Administration, Oral Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacokinetics Benzoxazole Benzoxazoles - chemical synthesis Benzoxazoles - chemistry Benzoxazoles - pharmacokinetics Biological and medical sciences CETP Cholesterol Ester Transfer Proteins - antagonists & inhibitors Cholesterol Ester Transfer Proteins - metabolism Cholesteryl ester transfer protein General and cellular metabolism. Vitamins HDL High density lipoprotein Medical sciences Mice Pharmacology. Drug treatments Structure-Activity Relationship
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