Do Tumor Cavitation and Sex in Resected Stage I Non-Small-Cell Lung Cancer Correlate with Prognosis?

Background Multiple factors have been reported as affecting the prognosis, and they affect the therapeutic outcomes of stage I non-small-cell lung cancer (NSCLC) patients. Most studies focus on patients receiving combined-modality therapy, whereas there are few studies that focus on patients undergo...

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Bibliographic Details
Published in:World journal of surgery 2009-03, Vol.33 (3), p.497-504
Main Authors: Wang, Meng, Zhao, Jing, Pan, Yi, Su, Yan-Jun, You, Jian, Zhao, Xiao-Liang, Wang, Chang-Li
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Cardiac Surgery
Epidermal Growth Factor Receptor
Female
General aspects
General Surgery
Humans
Kaplan-Meier Estimate
Lung Cancer
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
NSCLC Patient
Overall Survival
Pathologic Stage
Pneumology
Prognosis
Retrospective Studies
Risk Assessment
Sex Factors
Surgery
Thoracic Surgery
Tumors of the respiratory system and mediastinum
Vascular Surgery
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Summary:Background Multiple factors have been reported as affecting the prognosis, and they affect the therapeutic outcomes of stage I non-small-cell lung cancer (NSCLC) patients. Most studies focus on patients receiving combined-modality therapy, whereas there are few studies that focus on patients undergoing surgery alone. The aim of this study was to identify risk factors for disease relapse and unfavorable prognosis in stage I NSCLC patients treated with surgery alone. Methods A total of 315 stage I NSCLC patients who were treated with surgery alone as the definitive therapy were identified. Risk factors for disease relapse and unfavorable prognosis were estimated by univariate and multivariate analyses. Results Sex, tumor pathologic stage, and cavitating lung cancer were identified as independent risk factors for relapse and overall survival using the multivariate analysis. Sex, tumor pathologic stage, and cavitating lung cancer were identified as independent risk factors for early relapse, and sex and cavitating lung cancer were independent risk factors for late relapse. Conclusion Tumor cavitation, pathologic stage IB, and being male are predictors of poor outcome for patients with stage I NSCLC who undergo resection.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-008-9859-3