Favorable effect of immunomodulator therapy on bone mineral density in multiple sclerosis

Background Osteoporosis is a complication of multiple sclerosis (MS), especially if corticosteroid therapy is given. Little is known about the effect on bone of immunomodulatory therapy (IMT) for MS. Aim We sought to evaluate bone mass in patients with MS on IMT. Methods We measured bone mineral den...

Full description

Saved in:
Bibliographic Details
Published in:Irish journal of medical science 2009-03, Vol.178 (1), p.43-45
Main Authors: Shuhaibar, M., McKenna, M. J., Au-Yeong, M., Redmond, J. M. T.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adjuvants, Immunologic - therapeutic use
Adrenal Cortex Hormones - therapeutic use
Adult
Bone Density - drug effects
Confidence Intervals
Family Medicine
Female
France
General Practice
Glatiramer Acetate
Humans
Immunologic Factors - therapeutic use
Immunosuppressive Agents - therapeutic use
Interferon beta-1a
Interferon beta-1b
Interferon-beta - therapeutic use
Internal Medicine
Ireland
Male
Medicine
Medicine & Public Health
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Original Article
Osteoporosis - drug therapy
Osteoporosis - etiology
Osteoporosis - prevention & control
Peptides - therapeutic use
Spain
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Osteoporosis is a complication of multiple sclerosis (MS), especially if corticosteroid therapy is given. Little is known about the effect on bone of immunomodulatory therapy (IMT) for MS. Aim We sought to evaluate bone mass in patients with MS on IMT. Methods We measured bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) in 37 patients with MS who received IMT. Different IMTs were administered: interferon beta-1a in 70%, interferon beta-1b in 27% and Glatiramer in 3%. High-dose pulse corticosteroid therapy (intravenous methylprednisolone 500 mg) was given to 81% ranging from 1 to 17 courses. Results Both mean BMD Z-score at spine of 0.53 (CI, 0.15–0.92; P  = 0.0084) and mean BMD Z-score at femur of 0.72 (CI, 0.42–1.01; P  
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-008-0253-9