Diffusion-weighted magnetic resonance imaging of head and neck squamous cell carcinomas

Abstract Objective To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. Materials and methods DWI was obtained from 20 patients with histologically proven...

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Bibliographic Details
Published in:European journal of radiology 2008-12, Vol.68 (3), p.493-498
Main Authors: Friedrich, Klaus M, Matzek, Wolfgang, Gentzsch, Stephan, Sulzbacher, Irene, Czerny, Christian, Herneth, Andreas M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - diagnosis
Dermatology
Diffusion Magnetic Resonance Imaging - methods
Diffusion-weighted imaging
Head and neck cancer
Head and Neck Neoplasms - diagnosis
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic resonance imaging
Medical sciences
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Radiology
Reproducibility of Results
Sensitivity and Specificity
Squamous cell carcinoma
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Abstract Objective To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. Materials and methods DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b -value of 800 s/mm2 . For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. Results Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64 ± 0.28 × 10−3 mm2 /s), was significantly ( P < 0.0001) lower than that of the tumour-free soft tissue, (2.51 ± 0.82 × 10−3 mm2 /s). Conclusion DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2007.10.011