Application of Poly(amidoamine) Dendrimers for Use in Bionanomotor Systems

The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM) dendrimers are capable of supporting heavy meromyosin dependent actin motility of similar quality to that observed using nitrocellulose, and th...

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Bibliographic Details
Published in:Langmuir 2010-05, Vol.26 (9), p.6079-6082
Main Authors: Kolli, Madhukar B, Day, B. Scott, Takatsuki, Hideyo, Nalabotu, Siva K, Rice, Kevin M, Kohama, Kazuhiro, Gadde, Murali K, Kakarla, Sunil K, Katta, Anjaiah, Blough, Eric R
Format: Article
Language:English
Subjects:
Animals
Cattle
Chemistry
Collodion - chemistry
Colloidal state and disperse state
Dendrimers - chemistry
Electricity
Exact sciences and technology
General and physical chemistry
Movement
Myosins - metabolism
Nanotechnology - methods
Surface physical chemistry
Surface Properties
Tin Compounds - chemistry
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Summary:The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM) dendrimers are capable of supporting heavy meromyosin dependent actin motility of similar quality to that observed using nitrocellulose, and that microcontact printing of PAMAM dendrimers can be exploited to produce tracks of active myosin motors leading to the restricted motion of actin filaments across a patterned surface. These data suggest that the use of dendrimer surfaces will increase the applicability of using protein biomolecular motors for nanotechnological applications.
ISSN:0743-7463
1520-5827
DOI:10.1021/la100174h