Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs

Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after t...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010, Vol.109 (1), p.142-148
Main Authors: Seshima, Fumi, DDS, Ota, Mikio, DDS, PhD, Kinumatsu, Takashi, DDS, PhD, Shibukawa, Yoshihiro, DDS, PhD, Yamada, Satoru, DDS, PhD
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dental Cementum - drug effects
Dental Cementum - physiology
Dentistry
Dogs
Fibroblast Growth Factor 2 - pharmacology
Growth Substances - pharmacology
Immunoenzyme Techniques
Medical sciences
Otorhinolaryngology. Stomatology
Periodontal Ligament - drug effects
Periodontal Ligament - physiology
Proliferating Cell Nuclear Antigen - analysis
Proliferating Cell Nuclear Antigen - biosynthesis
Recombinant Proteins - pharmacology
Regeneration - drug effects
Root Resorption - prevention & control
Surgery
Tooth Ankylosis - prevention & control
Tooth Replantation
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Summary:Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination. Results After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group ( P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group ( P < .01). Conclusion The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.07.055