Detection of liver metastases: Gadoxetic acid-enhanced three-dimensional MR imaging versus ferucarbotran-enhanced MR imaging

Abstract Purpose To compare the diagnostic performance of gadoxetic acid-enhanced MRI with ferucarbotran-enhanced MRI for the detection of liver metastases. Materials and methods Thirty-six patients with 80 liver metastases who underwent gadoxetic acid-enhanced MRI using a three-dimensional volumetr...

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Bibliographic Details
Published in:European journal of radiology 2010-01, Vol.73 (1), p.131-136
Main Authors: Kim, Young Kon, Lee, Young Hwan, Kwak, Hyo Sung, Kim, Chong Soo, Han, Young Min
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Contrast agents
Contrast Media
Dextrans
Diagnosis, Differential
Female
Ferrosoferric Oxide
Gadolinium DTPA
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Imaging, Three-Dimensional - methods
Liver
Liver Neoplasms - diagnosis
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles
Male
Medical sciences
Middle Aged
Neoplasm
Radiology
Reproducibility of Results
Sensitivity and Specificity
Tumors
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Summary:Abstract Purpose To compare the diagnostic performance of gadoxetic acid-enhanced MRI with ferucarbotran-enhanced MRI for the detection of liver metastases. Materials and methods Thirty-six patients with 80 liver metastases who underwent gadoxetic acid-enhanced MRI using a three-dimensional volumetric interpolated technique and ferucarbotran-enhanced MRI with a mean interval of 7 days (range, 5–10 days) were included in this study. Two observers independently interpreted the two sets of images – the gadoxetic acid set (unenhanced, early dynamic and 20 min delayed phase images) and the ferucarbotran set (unenhanced and ferucarbotran-enhanced T2*-weighted-gradient echo and T2-weighted turbo spin echo images). Diagnostic accuracy was evaluated using the alternative-free response receiver operator characteristic (ROC) method. Sensitivity and positive predictive value were also evaluated. Results There was a trend toward increased areas under the ROC curve (Az values) for the gadoxetic acid set (0.950, 0.948) as compared with the ferucarbotran set (0.941 and 0.939) of images, but no significant difference was found for both observers ( p < 0.05). Sensitivities of the gadoxetic acid set (93.8% and 92.5%) were also slightly better than those of the ferucarbotran set (88.8% and 87.5%) with no significant difference ( p = 0.13). The two image sets showed similar positive predictive values (98.7% and 98.6%, respectively). Conclusions Gadoxetic acid-enhanced MRI showed comparable diagnostic performance to ferucarbotran-enhanced MRI for the detection of liver metastases.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2008.09.027