MR-elastography reveals degradation of tissue integrity in multiple sclerosis

In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation is increasingly recognized to be present from the very onset of the disease, and, although occult to conventional imaging techniques, may present a major cause of permanent neurological disability. Subtle tissu...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-02, Vol.49 (3), p.2520-2525
Main Authors: Wuerfel, Jens, Paul, Friedemann, Beierbach, Bernd, Hamhaber, Uwe, Klatt, Dieter, Papazoglou, Sebastian, Zipp, Frauke, Martus, Peter, Braun, Jürgen, Sack, Ingolf
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Adult
Brain
Brain - pathology
Brain Mapping - instrumentation
Brain Mapping - methods
Cell adhesion & migration
Elasticity Imaging Techniques - instrumentation
Elasticity Imaging Techniques - methods
Female
Gender
Humans
Magnetic resonance elastography
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Male
Middle Aged
MRI
Multiple sclerosis
Multiple Sclerosis - pathology
NMR
Nuclear magnetic resonance
Sex Factors
Software packages
Viscoelasticity
Young Adult
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Summary:In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation is increasingly recognized to be present from the very onset of the disease, and, although occult to conventional imaging techniques, may present a major cause of permanent neurological disability. Subtle tissue alterations significantly influence biomechanical properties given by stiffness and internal friction, that – in more accessible organs than the brain – are traditionally assessed by manual palpation during the clinical exam. The brain, however, is protected from our sense of touch, and thus our current knowledge on cerebral viscoelasticity is very limited. We developed a clinically feasible magnetic resonance elastography setup sensitive to subtle alterations of brain parenchymal biomechanical properties. Investigating 45 MS patients revealed a significant decrease (13%, P
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2009.06.018