Sculpting AMPA receptor formation and function by alternative RNA processing

AMPA receptors are ion channel tetramers that mediate fast excitatory neurotransmission in vertebrate brains. AMPAR functional properties as well as receptor biogenesis in the endoplasmic reticulum (ER) is influenced by RNA processing events, including adenosine-to-inosine RNA editing and alternativ...

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Bibliographic Details
Published in:RNA biology 2009-11, Vol.6 (5), p.517-521
Main Authors: Penn, Andrew C., Greger, Ingo H.
Format: Article
Language:English
Subjects:
Alternative Splicing
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Humans
Landes
Neurons
Organogenesis
Protein Multimerization
Protein Subunits
Proteins
Receptors, AMPA - genetics
RNA Editing
RNA Processing, Post-Transcriptional
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Summary:AMPA receptors are ion channel tetramers that mediate fast excitatory neurotransmission in vertebrate brains. AMPAR functional properties as well as receptor biogenesis in the endoplasmic reticulum (ER) is influenced by RNA processing events, including adenosine-to-inosine RNA editing and alternative splicing. Recoded sites line interfaces of subunit polypeptides, and are therefore ideally positioned to modulate receptor assembly. Moreover, the genomic arrangement of the R/G editing site within the splice donor of the alternative flip/flop exons may facilitate a cross-talk between these elements. Regulated mRNA recoding in response to neuronal activity would have the scope to sculpt AMPAR tetramers and in turn shape the response properties of a neuron.
ISSN:1547-6286
1555-8584
DOI:10.4161/rna.6.5.9552