Rationale and design for the PAINT randomized trial

We describe the rationale and design for the 'PercutAneous INTervention with biodegradable-polymer based paclitaxel-eluting or sirolimus-eluting versus bare stents for de novo coronary lesions - PAINT trial'. To evaluate two novel formulations of paclitaxel-eluting stent and the sirolimus-...

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Bibliographic Details
Published in:Arquivos brasileiros de cardiologia 2009-12, Vol.93 (6), p.547-553
Main Authors: Lemos, Pedro A, Moulin, Bruno, Perin, Marco A, Oliveira, Ludmilla A R R, Arruda, J Airton, Lima, Valter C, Lima, Antonio A G, Caramori, Paulo R A, Medeiros, Cesar R, Barbosa, Mauricio R, Brito, Jr, Fabio S, Ribeiro, Expedito E, Martinez, Eulógio E
Format: Article
Language:eng ; por
Subjects:
Absorbable Implants
Adolescent
Angioplasty, Balloon, Coronary - instrumentation
Angioplasty, Balloon, Coronary - methods
Brazil - epidemiology
Cardiovascular Agents - administration & dosage
Coronary Disease - pathology
Coronary Disease - therapy
Coronary Restenosis - prevention & control
Coronary Thrombosis - epidemiology
Coronary Thrombosis - etiology
Drug-Eluting Stents - adverse effects
Epidemiologic Methods
Humans
Paclitaxel - administration & dosage
Polymers - chemistry
Prosthesis Design
Sirolimus - administration & dosage
Treatment Outcome
Young Adult
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Summary:We describe the rationale and design for the 'PercutAneous INTervention with biodegradable-polymer based paclitaxel-eluting or sirolimus-eluting versus bare stents for de novo coronary lesions - PAINT trial'. To evaluate two novel formulations of paclitaxel-eluting stent and the sirolimus-eluting stent against a stent with the same metallic structure but without polymer coating or drug elution. The PAINT is a multicenter 3-arm randomized trial, conducted in Brazilian tertiary institutions, which included 275 patients allocated for the InfinniumR paclitaxel-eluting stent, the SupralimusR sirolimus-eluting stent or the Milennium MatrixR bare metal stent in a 2:2:1 ratio. Patients had de novo coronary lesions in native vessels with a diameter between 2.5 and 3.5 mm, amenable for treatment with a single stent of 29 mm or less in length. The primary objective was to compare the in-stent late loss at 9 months of both paclitaxel- and sirolimus-eluting versus the late loss of control bare metal stents. Important secondary objectives included the comparison in outcomes between sirolimus and paclitaxel stents, as well as the analysis of the incidence of major adverse cardiac events. The PAINT trial had a unique design that allowed for the evaluation of the safety and efficacy profiles of two novel drug-eluting stent formulations, with a biodegradable-polymer carrier and releasing paclitaxel or sirolimus, which were compared against a bare metal stent (primary objective). As the drug-eluting stents differed by the drug, but were identical otherwise, the trial also allowed the comparison of the anti-restenosis effects of sirolimus versus paclitaxel (secondary objective).
ISSN:1678-4170
DOI:10.1590/S0066-782X2009001200006