Erectile Dysfunction as a Predictor for Subsequent Atherosclerotic Cardiovascular Events: Findings from a Linked-Data Study

In spite of the mounting interest in the nexus between erectile dysfunction (ED) and cardiovascular (CV) diseases, there is little published information on the role of ED as a predictor for subsequent CV events. This study aimed to investigate the role of ED as a predictor for atherosclerotic CV eve...

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Bibliographic Details
Published in:Journal of sexual medicine 2010-01, Vol.7 (1pt1), p.192-202
Main Authors: Chew, Kew-Kim, Finn, Judith, Stuckey, Bronwyn, Gibson, Nicholas, Sanfilippo, Frank, Bremner, Alexandra, Thompson, Peter, Hobbs, Michael, Jamrozik, Konrad
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arterial Occlusive Diseases - epidemiology
Atherosclerotic Cardiovascular Events
Cohort Studies
Comorbidity
Coronary Artery Disease - epidemiology
Cross-Sectional Studies
Data Collection
Endothelial Dysfunction
Erectile Dysfunction
Health Surveys
Humans
Impotence, Vasculogenic - epidemiology
Incidence
Intracranial Arteriosclerosis - epidemiology
Linked-Data Study
Male
Middle Aged
Patient Admission - statistics & numerical data
Retrospective Studies
Risk Factors
Western Australia
Young Adult
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Summary:In spite of the mounting interest in the nexus between erectile dysfunction (ED) and cardiovascular (CV) diseases, there is little published information on the role of ED as a predictor for subsequent CV events. This study aimed to investigate the role of ED as a predictor for atherosclerotic CV events subsequent to the manifestation of ED. The investigation involved the retrospective study of data on a cohort of men with ED linked to hospital morbidity data and death registrations. By using the linked data, the incidence rates of atherosclerotic CV events subsequent to the manifestation of ED were estimated in men with ED and no atherosclerotic CV disease reported prior to the manifestation of ED. The risk of subsequent atherosclerotic CV events in men with ED was assessed by comparing these incidence rates with those in the general male population. Standardized incidence rate ratio (SIRR), comparing the incidence of atherosclerotic CV events subsequent to the manifestation of ED in a cohort of 1,660 men with ED to the incidence in the general male population. On the basis of hospital admissions and death registrations, men with ED had a statistically significantly higher incidence of atherosclerotic CV events (SIRR 2.2; 95% confidence interval 1.9, 2.4). There were significantly increased incidence rate ratios in all age groups younger than 70 years, with a statistically highly significant downward trend with increase of age (P
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2009.01576.x