A new construction for a potentiometric, enantioselective membrane electrode—its utilization to the S-captopril assay

A novel potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil) has been constructed. The graphite paste is impregnated with 2-hydroxy-3-trimethylammoniopropyl-β-cyclodextrin (as chloride salt) solution, 10−3 mol l−1. The potentiometric, enantio...

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Bibliographic Details
Published in:Talanta (Oxford) 1999-05, Vol.48 (5), p.1139-1143
Main Authors: Stefan, Raluca-Ioana, van Staden, Jacobus (Koos) F, Aboul-Enein, Hassan Y
Format: Article
Language:English
Subjects:
2-hydroxy-3-trimethylammoniopropyl-β-cyclodextrin
Analysis
Biological and medical sciences
Captopril
Enantioselective analysis
Enantioselective membrane electrode
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Potentiometric
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Summary:A novel potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil) has been constructed. The graphite paste is impregnated with 2-hydroxy-3-trimethylammoniopropyl-β-cyclodextrin (as chloride salt) solution, 10−3 mol l−1. The potentiometric, enantioselective membrane electrode can be used reliable for S-captopril assay as raw material and from Novocaptopril tablets, using a chronopotentiometry (zero current) technique, in the 10−6–10−2 mol l−1 concentration range (detection limit 2×10−7 mol l−1), with an average recovery of 99.99% (RSD=0.05%). The enantioselectivity was determined over R-captopril and d-proline. The response characteristics of the enantioselective, potentiometric membrane electrode were determined also for R-captopril. It was shown that only l-proline is the main interfering compound. The surface of the electrode can be regenerated by simply polishing, obtaining fresh surface ready to be used in a new assay.
ISSN:0039-9140
1873-3573
DOI:10.1016/S0039-9140(98)00335-X