FDG–PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis

The presence of activated macrophages is an important predictor of atherosclerotic plaque rupture. In this study, our aim was to determine the accuracy of 18 F- fluorodeoxyglucose (FDG) microPET imaging for quantifying aortic wall macrophage content in a rabbit model of atherosclerosis. Rabbits were...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2010-01, Vol.26 (1), p.41-48
Main Authors: Davies, John R., Izquierdo-Garcia, David, Rudd, James H. F., Figg, Nichola, Richards, Hugh K., Bird, Joseph L. E., Aigbirhio, Franklin I., Davenport, Anthony P., Weissberg, Peter L., Fryer, Tim D., Warburton, Elizabeth A.
Format: Article
Language:English
Subjects:
Animals
Aorta - diagnostic imaging
Aorta - drug effects
Atherosclerosis - diagnostic imaging
Atherosclerosis - drug therapy
Atherosclerosis - etiology
Atorvastatin Calcium
Cardiac Imaging
Cardiology
Catheterization
Cholesterol, Dietary
Diagnosis, Differential
Disease Models, Animal
Fluorodeoxyglucose F18
Heptanoic Acids - pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Imaging
Inflammation - diagnostic imaging
Inflammation - drug therapy
Inflammation - etiology
Macrophages - diagnostic imaging
Male
Medicine
Medicine & Public Health
Original Paper
Positron-Emission Tomography
Predictive Value of Tests
Pyrroles - pharmacology
Rabbits
Radiology
Radiopharmaceuticals
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Summary:The presence of activated macrophages is an important predictor of atherosclerotic plaque rupture. In this study, our aim was to determine the accuracy of 18 F- fluorodeoxyglucose (FDG) microPET imaging for quantifying aortic wall macrophage content in a rabbit model of atherosclerosis. Rabbits were divided into a control group and two groups post aortic balloon injury: 6 months high-cholesterol diet (HC); and 3 months HC followed by 3 months low-cholesterol diet plus statin (LCS). In vivo and ex vivo microPET, ex vivo well counting and histological quantification of the atherosclerotic aortas were performed for all groups. Macrophage density was greater in the HC group than the LCS group (5.1 ± 1.4% vs. 0.6 ± 0.7%, P  
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-009-9506-6