Reduced Pain with Use of Proprietary Hyaluronic Acid with Lidocaine for Correction of Nasolabial Folds: A Patient‐Blinded, Prospective, Randomized Controlled Trial

BACKGROUND Pain during and after implantation of dermal gel fillers is a consistent complaint of patients undergoing soft tissue augmentation. Reduction of pain during injection would increase patient comfort and improve the overall patient experience. OBJECTIVE To evaluate pain at the injection sit...

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Bibliographic Details
Published in:Dermatologic surgery 2010-01, Vol.36 (1), p.94-101
Main Authors: MONHEIT, GARY D., CAMPBELL, ROSS M., NEUGENT, HEIDI, NELSON, CANDI P., PRATHER, CHAD L., BACHTELL, NATHAN, ENG, DENISE, HOLMDAHL, LENA
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthetics, Local - administration & dosage
Antiarythmic agents
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cardiovascular system
Cosmetic Techniques
Dermatologic Agents - administration & dosage
Dermatology
Female
Humans
Hyaluronic Acid - administration & dosage
Lidocaine - administration & dosage
Male
Medical sciences
Middle Aged
Pain Measurement
Pain, Postoperative - prevention & control
Pharmacology. Drug treatments
Prospective Studies
Single-Blind Method
Skin Aging
Skin plastic surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:BACKGROUND Pain during and after implantation of dermal gel fillers is a consistent complaint of patients undergoing soft tissue augmentation. Reduction of pain during injection would increase patient comfort and improve the overall patient experience. OBJECTIVE To evaluate pain at the injection site during and after the injection of Prevelle SILK or Captique and to evaluate outcomes after 2 weeks. METHODS & MATERIALS In a patient‐blinded, prospective, randomized, split‐face design trial, a non‐animal‐derived hyaluronic acid based filler formulated with lidocaine (Prevelle SILK) was injected in one nasolabial fold (NLF), and the same filler without lidocaine (Captique) was injected in the contralateral NLF of 45 enrolled patients. Injection site pain was measured using a visual analogue scale at injection (time 0) and 15, 30, 45, and 60 minutes after injection. Patients were asked to return for an evaluation after 2 weeks and to complete a self‐assessment questionnaire during the follow‐up visit. RESULTS There was more than 50% less pain associated with the dermal gel with lidocaine than with the same filler without lidocaine at all time points (p
ISSN:1076-0512
1524-4725
DOI:10.1111/j.1524-4725.2009.01389.x