Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance

Summary background Insulin resistance, impaired glucose tolerance and type 2 diabetes are common in acromegalic subjects. The mechanism underlying this insulin resistance is unclear. design We investigated the levels of the adipocytokines, resistin, adiponectin and leptin in a group of 18 acromegali...

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Published in:Clinical endocrinology (Oxford) 2003-06, Vol.58 (6), p.736-742
Main Authors: Silha, Josef V., Krsek, Michal, Hana, Vaclav, Marek, Josef, Jezkova, Jana, Weiss, Vladimir, Murphy, Liam J.
Format: Article
Language:English
Subjects:
Acromegaly - blood
Adiponectin
Adult
Biological and medical sciences
Blood Glucose - analysis
Case-Control Studies
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Growth Hormone - blood
Hormones, Ectopic - blood
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Insulin - blood
Insulin Resistance
Insulin-Like Growth Factor Binding Protein 1 - blood
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - analysis
Intercellular Signaling Peptides and Proteins
Leptin - blood
Linear Models
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Proteins - analysis
Resistin
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Summary:Summary background Insulin resistance, impaired glucose tolerance and type 2 diabetes are common in acromegalic subjects. The mechanism underlying this insulin resistance is unclear. design We investigated the levels of the adipocytokines, resistin, adiponectin and leptin in a group of 18 acromegalic subjects and 18 control subjects matched for age, gender and body mass index. results Here we demonstrate for the first time significant elevation in adiponectin levels in acromegalic subjects compared to control subjects 12·5 ± 1·2 vs. 8·97 ± 1·1 mg/l, P = 0·029. The resistin levels were similar in acromegalic subjects and controls; 20·65 ± 2·99 vs. 19·03 ± 4·72 µg/l. No evidence of a correlation between adiponectin and insulin resistance as calculated from HOMA‐R was found. No correlation was observed either between adiponectin or resistin levels and GH levels, total IGF‐I or free IGF‐I levels. Leptin levels were significantly reduced in acromegalic subjects, 8·22 ± 2·26 vs. 18·3 ± 4·1 µg/l, P = 0·004. In control subjects, significant correlations between leptin levels and HOMA‐R and between resistin levels and HOMA‐R were observed. These relationships were not apparent in acromegalic subjects. conclusion From these data we conclude that changes in resistin and adiponectin levels are unlikely to account for the insulin resistance of acromegaly.
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2003.01789.x