Electron-beam tomography coronary artery calcium and cardiac events: A 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults

Conventional coronary artery disease (CAD) risk factors fail to explain nearly 50% of CAD events. This study examines the association between electron-beam tomography (EBT) coronary artery calcium (CAC) and cardiac events in initially asymptomatic low- to intermediate-risk individuals, with adjustme...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-05, Vol.107 (20), p.2571-2576
Main Authors: KONDOS, George T, HOFF, Julie Anne, SEVRUKOV, Alexander, DAVIGLUS, Martha L, GARSIDE, Daniel B, DEVRIES, Stephen S, CHOMKA, Eva V, KIANG LIU
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Biological and medical sciences
Calcinosis - diagnostic imaging
Calcinosis - epidemiology
Calcium - metabolism
Cardiology. Vascular system
Cohort Studies
Comorbidity
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - mortality
Coronary Artery Disease - physiopathology
Coronary heart disease
Coronary Vessels
Disease Progression
Female
Follow-Up Studies
Heart
Humans
Hypercholesterolemia - blood
Male
Medical sciences
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prevalence
Risk
Risk Assessment
Risk Factors
Sex Distribution
Tomography, X-Ray Computed
United States - epidemiology
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Summary:Conventional coronary artery disease (CAD) risk factors fail to explain nearly 50% of CAD events. This study examines the association between electron-beam tomography (EBT) coronary artery calcium (CAC) and cardiac events in initially asymptomatic low- to intermediate-risk individuals, with adjustment for the presence of hypercholesterolemia, hypertension, diabetes, and a history of cigarette smoking. The study was performed in 8855 initially asymptomatic adults 30 to 76 years old (26% women) who self-referred for EBT CAC screening. Conventional CAD risk factors were elicited by use of a questionnaire. After 37+/-12 months, information on the occurrence of cardiac events was collected and confirmed by use of medical records and death certificates. In men, events (n=192) were associated with the presence of CAC (RR=10.5, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000068341.61180.55