Relationship between plasma uridine and urinary urea excretion

Abstract To investigate whether the concentration of uridine in plasma is related to the urinary excretion of urea, 45 healthy male subjects with normouricemia and normal blood pressure were studied after providing informed consent. Immediately after collection of 24-hour urine, blood samples were d...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2010-03, Vol.59 (3), p.441-445
Main Authors: Ka, Tuneyoshi, Inokuchi, Taku, Tamada, Daisuke, Suda, Michio, Tsutsumi, Zenta, Okuda, Chihiro, Yamamoto, Asako, Takahashi, Sumio, Moriwaki, Yuji, Yamamoto, Tetsuya
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Creatinine - urine
Diet
Dietary Carbohydrates - metabolism
Dietary Fats - metabolism
Dietary Proteins - metabolism
Endocrinology & Metabolism
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Gout - metabolism
Homeostasis - physiology
Humans
Hypertension - blood
Insulin Resistance
Male
Middle Aged
Regression Analysis
Urea - urine
Uric Acid - urine
Uridine - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract To investigate whether the concentration of uridine in plasma is related to the urinary excretion of urea, 45 healthy male subjects with normouricemia and normal blood pressure were studied after providing informed consent. Immediately after collection of 24-hour urine, blood samples were drawn after an overnight fast except for water. The contents of ingested foods during the 24-hour urine collection period were described by the subjects and analyzed by a dietician. Simple regression analysis showed that plasma uridine was correlated with the urinary excretions of urea ( R = 0.41, P < .01), uric acid ( R = 0.36, P < .05), and uridine ( R = 0.30, P < .05), as well as uric acid clearance ( R = 0.35, P < .05) and purine intake ( R = 0.30, P < .05). In contrast, multiple regression analysis showed a positive relationship only between plasma uridine and urinary excretion of urea. These results suggest that an increase in de novo pyrimidine synthesis leads to an increased concentration of uridine in plasma via nitrogen catabolism in healthy subjects with normouricemia and normal blood pressure.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2009.07.032