Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii

The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F) were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable free radical 1,1-dipheny...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-07, Vol.87 (1), p.67-72
Main Authors: Dufall, K.G., Ngadjui, B.T., Simeon, K.F., Abegaz, B.M., Croft, K.D.
Format: Article
Language:English
Subjects:
Africa
Antioxidant
Antioxidants - chemistry
Antioxidants - isolation & purification
Biological and medical sciences
Biphenyl Compounds
Butylated Hydroxytoluene - chemistry
Flavonoids
Flavonoids - chemistry
Flavonoids - isolation & purification
Free Radical Scavengers - chemistry
General pharmacology
Low density lipoprotein
Medical sciences
Moraceae - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Picrates - chemistry
Quercetin
Quercetin - chemistry
Time Factors
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Summary:The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F) were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxy toluene (BHT), a common antioxidant used as a food additive. The prenylated flavonoids also inhibited Cu 2+-mediated oxidation of human low density lipoprotein (LDL). Dose–response studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC 50 values
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00108-9