Effect of added monovalent electrolytes on the myelin formation from charged lipids

Effect of NaCl concentration in hydrating solutions on the myelin formation from negatively charged cardiolipin. The scale bars represent 20 μm. (a) Myelin figures with onion-like structures at 0.010 M NaCl solution; (b) myelin figures at 0.150 M NaCl solution and (c) thinner myelin figures with som...

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Bibliographic Details
Published in:Journal of colloid and interface science 2010-08, Vol.348 (2), p.505-510
Main Authors: Lin, Meiyu, Li, Li, Qiu, Feng, Yang, Yuliang
Format: Article
Language:English
Subjects:
Animals
Cardiolipins - chemistry
Cattle
Charged lipid
Chemistry
Electrolyte
Electrolytes - pharmacology
Electrostatic interaction
Exact sciences and technology
General and physical chemistry
Microscopy
Myelin
Myelin Sheath - drug effects
Myelin Sheath - metabolism
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Summary:Effect of NaCl concentration in hydrating solutions on the myelin formation from negatively charged cardiolipin. The scale bars represent 20 μm. (a) Myelin figures with onion-like structures at 0.010 M NaCl solution; (b) myelin figures at 0.150 M NaCl solution and (c) thinner myelin figures with some irregular structures at 0.370 M NaCl solution. The effect of added monovalent electrolytes on the myelin formation of cardiolipin is investigated by optical microscopy observations. The results show that the myelin formation strongly depends on the concentration rather than the type of electrolytes. Myelin figures are observed only in a certain concentration range of electrolytes, and the diameter of the myelin figures decreases with increasing of the electrolyte concentration. Furthermore, the theoretical model of myelin formation for the neutral lipids developed by Huang–Zou–Witten [J.R. Huang, L.N. Zou, T.A. Witten, Eur. Phys. J. E. 18 (2005) 279–285] is extended to the charged membrane system by taking into account the electrostatic interaction to understand the mechanism of myelin formation. The theoretical results well produce our experimental results.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2010.05.016