Loading…
Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery
Despite improved myocardial protection strategies and enhanced surgical techniques, mortality after coronary artery bypass graft surgery (CABG) remains essentially unchanged. This may be because of the increasing age of patients who undergo primary CABG. Magnesium is an important regulator of vascul...
Saved in:
| Published in: | The American heart journal 2003-06, Vol.145 (6), p.1108-1113 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43 |
| container_end_page | 1113 |
| container_issue | 6 |
| container_start_page | 1108 |
| container_title | The American heart journal |
| container_volume | 145 |
| creator | Booth, John V Phillips-Bute, Barbara McCants, Charles B Podgoreanu, Mihai V Smith, Peter K Mathew, Joseph P Newman, Mark F |
| description | Despite improved myocardial protection strategies and enhanced surgical techniques, mortality after coronary artery bypass graft surgery (CABG) remains essentially unchanged. This may be because of the increasing age of patients who undergo primary CABG. Magnesium is an important regulator of vascular tone, reperfusion injury, and thrombosis. Therefore, we decided to investigate the relationship between serum magnesium levels and major adverse cardiac events (MACE) after CABG.
A total of 957 patients undergoing primary CABG were prospectively recruited into the Duke Cardiovascular database and had daily serum magnesium levels measured. Low magnesium was defined as |
| doi_str_mv | 10.1016/S0002-8703(03)00077-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73364952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002870303000772</els_id><sourcerecordid>73364952</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43</originalsourceid><addsrcrecordid>eNqFkVuLFDEQhYMo7uzqT1ACouhDa66d7ieRZb3AgA_qc6hOVw8Z-jJWukfm35t2Bhd8EQJJ5XwpKucw9kyKt1LI8t03IYQqKif0a6Hf5MK5Qj1gGylqV5TOmIds8xe5Ytcp7XNZqqp8zK6kcnXpnNyw_Xb6xRPSMvABdiOmmE89HrHnB8I2hjllYT8Rh_aIlJAHoDZC4JkZswjdjMTDRNMIdOJAuTzx5nSAlPiOsszTQrt8-YQ96qBP-PSy37AfH---334utl8_fbn9sC2CkfVcWCPAthW2Vdk2YBttainBKduhDLJRRiE0zlUlVM6CQ1W1UGkXdF0rKzujb9irc98DTT8XTLMfYgrY9zDitCTvtC5NbVUGX_wD7qeFxjybl9bUGbHaZcqeqUBTSoSdP1Ac8l-9FH6Nwv-Jwq8--3WtUfi1-_NL96UZsL1_dfE-Ay8vAKQAfUcwhpjuOVM5ba3N3Pszh9m0Y0TyKUQcQ06HMMy-neJ_RvkNXE2mKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549952537</pqid></control><display><type>article</type><title>Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery</title><source>ScienceDirect Freedom Collection</source><creator>Booth, John V ; Phillips-Bute, Barbara ; McCants, Charles B ; Podgoreanu, Mihai V ; Smith, Peter K ; Mathew, Joseph P ; Newman, Mark F</creator><creatorcontrib>Booth, John V ; Phillips-Bute, Barbara ; McCants, Charles B ; Podgoreanu, Mihai V ; Smith, Peter K ; Mathew, Joseph P ; Newman, Mark F</creatorcontrib><description>Despite improved myocardial protection strategies and enhanced surgical techniques, mortality after coronary artery bypass graft surgery (CABG) remains essentially unchanged. This may be because of the increasing age of patients who undergo primary CABG. Magnesium is an important regulator of vascular tone, reperfusion injury, and thrombosis. Therefore, we decided to investigate the relationship between serum magnesium levels and major adverse cardiac events (MACE) after CABG.
A total of 957 patients undergoing primary CABG were prospectively recruited into the Duke Cardiovascular database and had daily serum magnesium levels measured. Low magnesium was defined as <1.8 mmol/L
−1 at any point during the first 8 days after surgery. Adverse events were defined as Q-wave infarction or death measured 1 year after surgery. A Kaplan-Meier survival analysis was performed, followed by a Cox proportional hazards model, to account for other known predictors of adverse events.
In the low magnesium group, 12.3% of patients had adverse events, compared with 9.2% of patients in the normal magnesium group. A serum magnesium level <1.8 mmol/L
−1 decreased the event-free survival rate (2-fold increased risk of death or myocardial infarction at 1 year; hazard ratio 2.0, 95% CI 1.19–3.37).
We demonstrated a robust relationship between low serum magnesium levels after CABG and a 2-fold increased incidence of Q-wave infarction and all-cause mortality rate as long as 1 year after surgery. This relationship is independent of known preoperative and intraoperative predictors of adverse outcomes. This study provides a rationale for a randomized controlled trial of magnesium therapy during CABG.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/S0002-8703(03)00077-2</identifier><identifier>PMID: 12796771</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers - blood ; Cause of Death ; Chronic obstructive pulmonary disease ; Coronary Artery Bypass - mortality ; Coronary vessels ; Female ; Heart attacks ; Humans ; Magnesium - blood ; Male ; Medical sciences ; Middle Aged ; Mortality ; Myocardial Infarction - blood ; Myocardial Infarction - mortality ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Statistics, Nonparametric ; Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors</subject><ispartof>The American heart journal, 2003-06, Vol.145 (6), p.1108-1113</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43</citedby><cites>FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14873555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12796771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Booth, John V</creatorcontrib><creatorcontrib>Phillips-Bute, Barbara</creatorcontrib><creatorcontrib>McCants, Charles B</creatorcontrib><creatorcontrib>Podgoreanu, Mihai V</creatorcontrib><creatorcontrib>Smith, Peter K</creatorcontrib><creatorcontrib>Mathew, Joseph P</creatorcontrib><creatorcontrib>Newman, Mark F</creatorcontrib><title>Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Despite improved myocardial protection strategies and enhanced surgical techniques, mortality after coronary artery bypass graft surgery (CABG) remains essentially unchanged. This may be because of the increasing age of patients who undergo primary CABG. Magnesium is an important regulator of vascular tone, reperfusion injury, and thrombosis. Therefore, we decided to investigate the relationship between serum magnesium levels and major adverse cardiac events (MACE) after CABG.
A total of 957 patients undergoing primary CABG were prospectively recruited into the Duke Cardiovascular database and had daily serum magnesium levels measured. Low magnesium was defined as <1.8 mmol/L
−1 at any point during the first 8 days after surgery. Adverse events were defined as Q-wave infarction or death measured 1 year after surgery. A Kaplan-Meier survival analysis was performed, followed by a Cox proportional hazards model, to account for other known predictors of adverse events.
In the low magnesium group, 12.3% of patients had adverse events, compared with 9.2% of patients in the normal magnesium group. A serum magnesium level <1.8 mmol/L
−1 decreased the event-free survival rate (2-fold increased risk of death or myocardial infarction at 1 year; hazard ratio 2.0, 95% CI 1.19–3.37).
We demonstrated a robust relationship between low serum magnesium levels after CABG and a 2-fold increased incidence of Q-wave infarction and all-cause mortality rate as long as 1 year after surgery. This relationship is independent of known preoperative and intraoperative predictors of adverse outcomes. This study provides a rationale for a randomized controlled trial of magnesium therapy during CABG.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cause of Death</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coronary Artery Bypass - mortality</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Magnesium - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - mortality</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkVuLFDEQhYMo7uzqT1ACouhDa66d7ieRZb3AgA_qc6hOVw8Z-jJWukfm35t2Bhd8EQJJ5XwpKucw9kyKt1LI8t03IYQqKif0a6Hf5MK5Qj1gGylqV5TOmIds8xe5Ytcp7XNZqqp8zK6kcnXpnNyw_Xb6xRPSMvABdiOmmE89HrHnB8I2hjllYT8Rh_aIlJAHoDZC4JkZswjdjMTDRNMIdOJAuTzx5nSAlPiOsszTQrt8-YQ96qBP-PSy37AfH---334utl8_fbn9sC2CkfVcWCPAthW2Vdk2YBttainBKduhDLJRRiE0zlUlVM6CQ1W1UGkXdF0rKzujb9irc98DTT8XTLMfYgrY9zDitCTvtC5NbVUGX_wD7qeFxjybl9bUGbHaZcqeqUBTSoSdP1Ac8l-9FH6Nwv-Jwq8--3WtUfi1-_NL96UZsL1_dfE-Ay8vAKQAfUcwhpjuOVM5ba3N3Pszh9m0Y0TyKUQcQ06HMMy-neJ_RvkNXE2mKg</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Booth, John V</creator><creator>Phillips-Bute, Barbara</creator><creator>McCants, Charles B</creator><creator>Podgoreanu, Mihai V</creator><creator>Smith, Peter K</creator><creator>Mathew, Joseph P</creator><creator>Newman, Mark F</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery</title><author>Booth, John V ; Phillips-Bute, Barbara ; McCants, Charles B ; Podgoreanu, Mihai V ; Smith, Peter K ; Mathew, Joseph P ; Newman, Mark F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cause of Death</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Coronary Artery Bypass - mortality</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Magnesium - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - mortality</topic><topic>Predictive Value of Tests</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Booth, John V</creatorcontrib><creatorcontrib>Phillips-Bute, Barbara</creatorcontrib><creatorcontrib>McCants, Charles B</creatorcontrib><creatorcontrib>Podgoreanu, Mihai V</creatorcontrib><creatorcontrib>Smith, Peter K</creatorcontrib><creatorcontrib>Mathew, Joseph P</creatorcontrib><creatorcontrib>Newman, Mark F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Booth, John V</au><au>Phillips-Bute, Barbara</au><au>McCants, Charles B</au><au>Podgoreanu, Mihai V</au><au>Smith, Peter K</au><au>Mathew, Joseph P</au><au>Newman, Mark F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>145</volume><issue>6</issue><spage>1108</spage><epage>1113</epage><pages>1108-1113</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Despite improved myocardial protection strategies and enhanced surgical techniques, mortality after coronary artery bypass graft surgery (CABG) remains essentially unchanged. This may be because of the increasing age of patients who undergo primary CABG. Magnesium is an important regulator of vascular tone, reperfusion injury, and thrombosis. Therefore, we decided to investigate the relationship between serum magnesium levels and major adverse cardiac events (MACE) after CABG.
A total of 957 patients undergoing primary CABG were prospectively recruited into the Duke Cardiovascular database and had daily serum magnesium levels measured. Low magnesium was defined as <1.8 mmol/L
−1 at any point during the first 8 days after surgery. Adverse events were defined as Q-wave infarction or death measured 1 year after surgery. A Kaplan-Meier survival analysis was performed, followed by a Cox proportional hazards model, to account for other known predictors of adverse events.
In the low magnesium group, 12.3% of patients had adverse events, compared with 9.2% of patients in the normal magnesium group. A serum magnesium level <1.8 mmol/L
−1 decreased the event-free survival rate (2-fold increased risk of death or myocardial infarction at 1 year; hazard ratio 2.0, 95% CI 1.19–3.37).
We demonstrated a robust relationship between low serum magnesium levels after CABG and a 2-fold increased incidence of Q-wave infarction and all-cause mortality rate as long as 1 year after surgery. This relationship is independent of known preoperative and intraoperative predictors of adverse outcomes. This study provides a rationale for a randomized controlled trial of magnesium therapy during CABG.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>12796771</pmid><doi>10.1016/S0002-8703(03)00077-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 2003-06, Vol.145 (6), p.1108-1113 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73364952 |
| source | ScienceDirect Freedom Collection |
| subjects | Aged Biological and medical sciences Biomarkers - blood Cause of Death Chronic obstructive pulmonary disease Coronary Artery Bypass - mortality Coronary vessels Female Heart attacks Humans Magnesium - blood Male Medical sciences Middle Aged Mortality Myocardial Infarction - blood Myocardial Infarction - mortality Predictive Value of Tests Proportional Hazards Models Prospective Studies Statistics, Nonparametric Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors |
| title | Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T23%3A29%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20serum%20magnesium%20level%20predicts%20major%20adverse%20cardiac%20events%20after%20coronary%20artery%20bypass%20graft%20surgery&rft.jtitle=The%20American%20heart%20journal&rft.au=Booth,%20John%20V&rft.date=2003-06-01&rft.volume=145&rft.issue=6&rft.spage=1108&rft.epage=1113&rft.pages=1108-1113&rft.issn=0002-8703&rft.eissn=1097-6744&rft.coden=AHJOA2&rft_id=info:doi/10.1016/S0002-8703(03)00077-2&rft_dat=%3Cproquest_cross%3E73364952%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c419t-540a5d8ed86dba5b34911a725fe1c1b242eab7786a875a7e28da837c399251f43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1549952537&rft_id=info:pmid/12796771&rfr_iscdi=true |