Jaw bone changes in rats after treatment with zoledronate and pamidronate

Objective The aim of this study was to histopathologically evaluate the effects of pamidronate and zoledronate on the mandible in an animal model. Study design Sixty female Sprague-Dawley rats were used in this study. Animals were divided into 6 groups (10 per group): control-1 (C1), injected with s...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010-03, Vol.109 (3), p.385-391
Main Authors: Senel, Figen Cizmeci, DDS, PhD, Duman, Mine Kadıoglu, MD, Muci, Efnan, MD, Cankaya, Mustafa, DDS, Pampu, A. Alper, DDS, PhD, Ersoz, Safak, MD, Gunhan, Omer, DDS, PhD
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone Density Conservation Agents - adverse effects
Bones, joints and connective tissue. Antiinflammatory agents
Dentistry
Diphosphonates - adverse effects
Disease Models, Animal
Female
Femur - drug effects
Femur - pathology
Imidazoles - adverse effects
Inflammation - chemically induced
Inflammation - pathology
Mandible - drug effects
Mandible - pathology
Medical sciences
Osteonecrosis - chemically induced
Osteonecrosis - pathology
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Single-Blind Method
Surgery
Time Factors
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Summary:Objective The aim of this study was to histopathologically evaluate the effects of pamidronate and zoledronate on the mandible in an animal model. Study design Sixty female Sprague-Dawley rats were used in this study. Animals were divided into 6 groups (10 per group): control-1 (C1), injected with saline solution for 6 weeks; zoledronate-1 (ZA1), injected with zoledronate for 6 weeks; pamidronate-1 (PA1), injected with pamidronate for 6 weeks; control-2 (C2), injected with saline solution for 8 weeks; zoledronate-2 (ZA2), injected with zoledronate for 8 weeks; and pamidronate-2 (PA2), injected with pamidronate for 8 weeks. No dental procedures were performed on the animals. Rats were killed 2 days after the end of drug therapy, and the posterior and anterior mandible and femur of each rat were evaluated histopathologically. Results Histological examination revealed inflammation limited to the posterior mandible of the ZA2 and PA2 groups; the anterior mandible and femur were not affected. Soft tissue necrosis was evident in one rat in the ZA2 group. Conclusion Specific, bisphosphonate-asociated inflammatory bony and soft tissue changes were observed in the mandible, suggesting that these drugs may set the stage for altered healing associated with the development of bisphosphonate-related osteonecrosis of the jaw.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2009.10.011