Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis

Abstract Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Ja...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2010-04, Vol.16 (2), p.144-149
Main Authors: Higuchi, Wataru, Takano, Tomomi, Iwao, Yasuhisa, Ozaki, Kyoko, Isobe, Hirokazu, Yamamoto, Tatsuo, Hung, Wei-Chun, Teng, Lee-Jene, Shimazaki, Tetsuya, Honda, Akihito, Higashide, Masato, Hanaki, Hideaki
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Bacterial Toxins - biosynthesis
Cellulitis - microbiology
Child
Community-Acquired Infections - microbiology
Drug Resistance, Bacterial
Enterotoxins - genetics
Exotoxins - biosynthesis
Genes, Bacterial
Hematology, Oncology and Palliative Medicine
Humans
Infectious Diseases
Leukocidins - biosynthesis
Male
Medical Microbiology
Medicine
Medicine & Public Health
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - metabolism
Phylogeny
Staphylococcal Infections - microbiology
Taiwan
Trans-Activators - genetics
Virology
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Summary:Abstract Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Japanese boy. This MRSA was PVL-positive and belonged to the Taiwanese multiple drug-resistant CA-MRSA clone with the genotype of ST59, staphylococcal cassette chromosome mec (SCC mec ) VII (SCC mec V, according to recent reclassification), agr 1a (a novel agr 1 subtype), and SaPI (which carried seb1 , a newly designated variant seb gene). This study demonstrates the first isolation of the Taiwanese PVL-positive ST59 MRSA clone in Japan. The data also demonstrate novel subtypes in agr 1 and seb and suggest that a combination of agr 1a, seb1 , and PVL could contribute to cellulitis (and its recurrence). Recently, a variety of PVL-positive MRSA clones are accumulating in Japan.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-010-0029-9