Irregular Changes in the Structure of Flowing Blood at Low Flow Conditions

The structural organization of the dispersed phase of blood was studied by measuring the conductance (G) and the capacitance (C) of red blood cell (RBC) suspensions flowing in a vertical channel. Steady-state C and G signals exhibit erratic fluctuations around mean values; the root mean square of th...

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Bibliographic Details
Published in:Annals of biomedical engineering 2009-12, Vol.37 (12), p.2488-2496
Main Authors: Pribush, Alexander, Meiselman, Herbert J, Meyerstein, Dan, Meyerstein, Naomi
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Blood Flow Velocity - physiology
Classical Mechanics
Computer Simulation
Erythrocytes - cytology
Erythrocytes - physiology
Fluctuations
Humans
Models, Cardiovascular
Stream profiles
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Summary:The structural organization of the dispersed phase of blood was studied by measuring the conductance (G) and the capacitance (C) of red blood cell (RBC) suspensions flowing in a vertical channel. Steady-state C and G signals exhibit erratic fluctuations around mean values; the root mean square of the fluctuating signals decreases rapidly as the average flow rate () increases from 0.21 to ~4.17 mm/s and then less rapidly at higher velocities. The intensity of oscillations is substantially reduced for suspensions with weaker aggregating media. Analysis of the fluctuations performed in the framework of the equivalent electrical circuits for flowing blood gives rise to the following conclusions: (1) Instantaneous hematocrit (Hct) and velocity cross-stream profiles are non-smooth functions of radial position. (2) Oscillations of conductance at low flow conditions reflect irregular changes in the RBC network structure caused by fluctuations of aggregation-disaggregation equilibrium in the non-uniform shear field. (3) A transformation of the rheological behavior of RBC suspensions from shear-thinning to shear-thickening in a low flow regime amplifies fluctuations of aggregation-disaggregation equilibrium.
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-009-9800-4