Low COX2 in tumor and upregulation in stroma mark laryngeal squamous cell carcinoma progression

Objectives/Hypothesis: Invasive squamous cell carcinomas (SCC) of the larynx, like most solid tumors, are surrounded by a reactive stroma, in which cancer associated fibroblasts (CAFs) are the predominant cell type. This mesenchymal reaction may affect cancer progression multiply. The proinflammator...

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Published in:The Laryngoscope 2009-09, Vol.119 (9), p.1723-1729
Main Authors: Kourelis, Konstantinos, Vandoros, Gerasimos, Kourelis, Theodoros, Papadas, Theodoros, Goumas, Panos, Sotiropoulou-Bonikou, Georgia
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
cancer progression
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Cyclooxygenase 2 - metabolism
cyclooxygenase-2
Disease Progression
Disease-Free Survival
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - mortality
Larynx
Male
Medical sciences
Middle Aged
myofibroblast
Otorhinolaryngology. Stomatology
stroma
Tumors
Up-Regulation - physiology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Objectives/Hypothesis: Invasive squamous cell carcinomas (SCC) of the larynx, like most solid tumors, are surrounded by a reactive stroma, in which cancer associated fibroblasts (CAFs) are the predominant cell type. This mesenchymal reaction may affect cancer progression multiply. The proinflammatory enzyme cyclooxygenase‐2 (COX‐2) has been correlated with head and neck cancer. This study aims to explore the impact of epithelial and stromal COX‐2 expression on SCC behavior. Study Design: Retrospective case review study performed in a tertiary health center institution. Methods: Double immunohistochemistry of COX‐2 and the CAF marker α‐smooth muscle actin (α‐SMA) was utilized in 97 laryngeal cancer patients. Follow‐up data were collected in 52 cases. Results: Low COX‐2 immunostaining in cancer cells was associated with advanced grade (P = .044) and shorter recurrence‐free period (P = .035). CAF expression was positively correlated with the grade of the infiltrating tumor (P = .030). Conclusions: In laryngeal SCCs, COX‐2 may exert its deleterious effect by alterations in the tumor microenvironment. CAF‐derived, COX‐2‐mediated paracrine influences on malignant cells possibly facilitate cancer progression. Overlooking the stromal remodeling could account for unsuccessful treatments of epithelial neoplasms. Laryngoscope, 2009
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.20569