Palladium-Catalyzed Benzylic Addition of 2-Methyl Azaarenes to N-Sulfonyl Aldimines via C−H Bond Activation

An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C−H bond activation has been developed. This reaction represents a very efficient methodology for the synthe...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2010-03, Vol.132 (11), p.3650-3651
Main Authors: Qian, Bo, Guo, Shengmei, Shao, Jianping, Zhu, Qiming, Yang, Lei, Xia, Chungu, Huang, Hanmin
Format: Article
Language:English
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Summary:An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines under neutral conditions via C−H bond activation has been developed. This reaction represents a very efficient methodology for the synthesis of heterocycle-containing amines and thus opens a new way to access amines through C−H bond activation.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja910104n