Prognostic significance of p-STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

Aim:  To better predict treatment responses for managing bulky cervical carcinoma with neoadjuvant chemotherapy (NAC). Methods:  The expression of p‐STAT3 was analyzed by immunohistochemistry using paraffin‐embedded pretreatment cervical biopsy tissues. The study included 29 patients with bulky IB t...

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Published in:The journal of obstetrics and gynaecology research 2010-04, Vol.36 (2), p.304-310
Main Authors: Choi, Chel Hun, Song, Sang Yong, Kang, Heeseok, Lee, Yoo-Young, Kim, Chul-Jung, Lee, Jeong-Won, Kim, Tae-Joong, Kim, Byoung-Gie, Lee, Je-Ho, Bae, Duk-Soo
Format: Article
Language:English
Subjects:
Adult
Aged
bulky cervical carcinoma
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Disease-Free Survival
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Middle Aged
Neoadjuvant Therapy
p-STAT3
Phosphorylation
Prognosis
STAT3 Transcription Factor - metabolism
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
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Summary:Aim:  To better predict treatment responses for managing bulky cervical carcinoma with neoadjuvant chemotherapy (NAC). Methods:  The expression of p‐STAT3 was analyzed by immunohistochemistry using paraffin‐embedded pretreatment cervical biopsy tissues. The study included 29 patients with bulky IB to IIA cervical squamous cell carcinoma treated with NAC. Results:  Twenty (69.0%) of 29 patients were scored as p‐STAT3‐positive. Pathological response to chemotherapy (complete response or residual tumor with less than 3 mm stromal invasion) was observed in eight patients (27.6%). The p‐STAT3‐positive patients had a longer disease‐free survival compared to p‐STAT3‐negative patients (P = 0.03), though they had more frequent clinical nodal involvement (P = 0.046). Conclusion:  Pretreatment assessment of p‐STAT3 expression may provide additional information for the identification of patients with cervical cancer who have a favorable prognosis.
ISSN:1341-8076
1447-0756
DOI:10.1111/j.1447-0756.2009.01131.x