Understanding the mechanism of proton movement linked to oxygen reduction in cytochrome c oxidase: lessons from other proteins

Cytochrome c oxidase is a large intrinsic membrane protein designed to use the energy of electron transfer and oxygen reduction to pump protons across a membrane. The molecular mechanism of the energy conversion process is not understood. Other proteins with simpler, better resolved structures have...

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Bibliographic Details
Published in:FEBS Letters 2003-06, Vol.545 (1), p.47-51
Main Authors: Mills, Denise A, Ferguson-Miller, Shelagh
Format: Article
Language:English
Subjects:
CcO, cytochrome c oxidase
Cytochrome c oxidase
Electron Transport Complex IV - chemistry
Electron Transport Complex IV - metabolism
Ion Transport
Ligands
MD, molecular dynamics
Models, Molecular
Oxidation-Reduction
Oxygen - metabolism
Oxyhemoglobins - chemistry
Oxyhemoglobins - metabolism
Oxyhemoglobins - physiology
Propionate
Proteins - chemistry
Proteins - metabolism
Proton pathway
Proton Pumps - chemistry
Proton Pumps - metabolism
Protons
Redox Bohr
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Summary:Cytochrome c oxidase is a large intrinsic membrane protein designed to use the energy of electron transfer and oxygen reduction to pump protons across a membrane. The molecular mechanism of the energy conversion process is not understood. Other proteins with simpler, better resolved structures have been more completely defined and offer insight into possible mechanisms of proton transfer in cytochrome c oxidase. Important concepts that are illustrated by these model systems include the ideas of conformational change both close to and at a distance from the triggering event, and the formation of a transitory water-linked proton pathway during a catalytic cycle. Evidence for the applicability of these concepts to cytochrome c oxidase is discussed.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(03)00392-2