Control of mixed microbial cultures via specific cell adhesion

A new method for manipulating the steady‐state behavior of a mixed culture is introduced. The method makes use of differences in adherence properties between competing populations to maintain a desired population ratio. The very specific nature of some ligand‐to‐cell interactions allows precise mani...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1989-01, Vol.33 (5), p.638-649
Main Authors: Roos, Joseph W., Hjortso, Martin A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
fermentation
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
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Summary:A new method for manipulating the steady‐state behavior of a mixed culture is introduced. The method makes use of differences in adherence properties between competing populations to maintain a desired population ratio. The very specific nature of some ligand‐to‐cell interactions allows precise manipulation of even closely related populations. The control method is illustrated by analysis and simulations of models of a competitive mixed culture and a culture of an unstable recombinant organism. In both cases, retention of the disadvantaged population via cell adhesion results in creation of a stable coexistence steady state over a range of operating conditions.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260330518