Sulfido-peptide leukotrienes in coronary heart disease - relationship with disease instability and myocardial ischaemia

Eur J Clin Invest 2010; 40 (3): 258–272 Background  Urinary excretion of leukotriene (LT) E4 is an index of LTC4 biosynthesis and platelet–neutrophil interactions, which may occur in coronary heart disease and contribute to myocardial ischaemia. Enhanced LTC4 biosynthesis may be a consequence of myo...

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Published in:European journal of clinical investigation 2010-03, Vol.40 (3), p.258-272
Main Authors: De Caterina, R., Giannessi, D., Lazzerini, G., Bernini, W., Sicari, R., Cupelli, F., Lenzi, S., Rugolotto, M. M., Madonna, R., Maclouf, J.
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - urine
Adult
Aged
Angina Pectoris - urine
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - urine
Blood and lymphatic vessels
Cardiology. Vascular system
Chromatography, High Pressure Liquid
Coronary artery plaque
Coronary heart disease
Cross-Sectional Studies
Female
General aspects
Heart
Humans
Immunoenzyme Techniques
leukocytes
Leukotriene E4 - urine
leukotrienes
Male
Medical sciences
Middle Aged
Myocardial Infarction - urine
myocardial ischaemia
thrombosis
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Summary:Eur J Clin Invest 2010; 40 (3): 258–272 Background  Urinary excretion of leukotriene (LT) E4 is an index of LTC4 biosynthesis and platelet–neutrophil interactions, which may occur in coronary heart disease and contribute to myocardial ischaemia. Enhanced LTC4 biosynthesis may be a consequence of myocardial ischaemia or be linked to its pathogenetic substrate. Methods and results  Overnight urine collections were obtained from 17 patients with chronic stable angina, three patients with Prinzmetal’s angina, 16 patients with non ST‐elevation acute coronary syndromes (NSTE‐ACS) and six patients with acute ST‐elevation myocardial infarction (STEMI). LTE4 excretion was measured by enzyme immunoassay after HPLC separation. Compared with healthy controls (51·1 ± 21·3 pg mg−1 creatinine, mean ± SD, n = 11) and with non‐coronary cardiac controls (36·6 ± 9·8 pg mg−1 creatinine, n = 9), LTE4 excretion was unchanged in stable angina (40·5 ± 25·8 pg mg−1 creatinine), but significantly (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2010.02261.x