Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii

In the search for acetylcholinesterase (AChE) inhibitors from Indian medicinal plants, via bioassay-guided isolation, a carbazole alkaloid, mahanimbine [3, 5-dimethyl-3-(4- methylpent-3-enyl)-11H-pyrano [5, 6-a] carbazole], was isolated from the petroleum ether extract of the leaves of Murraya koeni...

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Bibliographic Details
Published in:Phytotherapy research 2010-04, Vol.24 (4), p.629-631
Main Authors: Kumar, N. Satheesh, Mukherjee, Pulok K, Bhadra, S, Saha, B.P, Pal, B.C
Format: Article
Language:English
Subjects:
acetylcholinesterase inhibition
AChE
Biological and medical sciences
carbazole alkaloid
Carbazoles - chemistry
Carbazoles - isolation & purification
Carbazoles - pharmacology
Cholinesterase Inhibitors - isolation & purification
Chromatography, Thin Layer
General pharmacology
Indian medicinal plant
mahanimbine
Medical sciences
Murraya - chemistry
Murraya koenigii
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
spices
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Summary:In the search for acetylcholinesterase (AChE) inhibitors from Indian medicinal plants, via bioassay-guided isolation, a carbazole alkaloid, mahanimbine [3, 5-dimethyl-3-(4- methylpent-3-enyl)-11H-pyrano [5, 6-a] carbazole], was isolated from the petroleum ether extract of the leaves of Murraya koenigii. Inhibition of AChE was evaluated based on Ellman's method using 96-well microplate readers. Mahanimbine inhibited AChE activity in a dose-dependent manner with an IC₅₀ value of 0.03 ± 0.09 mg/mL, while galantamine was used as a standard. The AChE inhibitory activity of this carbazole alkaloid has not been reported so far, and this study is the first to reveal this activity in carbazole alkaloid mahanimbine, isolated from Murraya koenigii. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.3023