Prevalence and clinical characteristics of ankylosing spondylitis in Iceland - a nationwide study

To determine the prevalence and clinical characteristics of ankylosing spondylitis (AS) in the Icelandic population, which carries a high prevalence of HLA-B27. A nationwide search was performed by screening hospital records and private rheumatology services for cases of AS in association with an on...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2010-05, Vol.28 (3), p.333-340
Main Authors: GEIRSSON, A. J, EYJOLFSDOTTIR, H, BJORNSDOTTIR, G, KRISTJANSSON, K, GUDBJORNSSON, B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Biological and medical sciences
Diseases of the osteoarticular system
Diseases of the spine
European Continental Ancestry Group - statistics & numerical data
Female
HLA-B27 Antigen - genetics
Humans
Iceland - epidemiology
Incidence
Inflammatory joint diseases
Male
Medical sciences
Prevalence
Severity of Illness Index
Spondylitis, Ankylosing - epidemiology
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - physiopathology
Surveys and Questionnaires
Young Adult
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Summary:To determine the prevalence and clinical characteristics of ankylosing spondylitis (AS) in the Icelandic population, which carries a high prevalence of HLA-B27. A nationwide search was performed by screening hospital records and private rheumatology services for cases of AS in association with an on-going genetic study. Individuals diagnosed with AS according to the modified New York criteria were asked to participate in the study by answering a standardised questionnaire and to undergo an interview and clinical evaluation. A total of 256 individuals fulfilled the modified New York classification criteria for AS (169 male, 87 female); 84% of these individuals were HLA-B27 positive vs. 15% in the population (p
ISSN:0392-856X
1593-098X