Treatment of plaque psoriasis with the two-compound product calcipotriol/betamethasone dipropionate versus both monotherapies: An immunohistochemical study

The combination of calcipotriol (Cp) and topical corticosteroids increases efficacy and reduces side effects as compared to monotherapies. Previous studies suggest that such combinations may have an added value with respect to reduction of T-cell subsets. A two-compound product consisting of Cp and...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2010-01, Vol.21 (1), p.13-22
Main Authors: van der Velden, Haike M. J., Pasch, Marcel C., van Erp, Piet E. J., van Lingen, Rosanne G., Otero, Marisol E., de Boer-van Huizen, Roelie T., van de Kerkhof, Peter C. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Betamethasone - administration & dosage
Betamethasone - analogs & derivatives
betamethasone dipropionate
Biomarkers - metabolism
calcipotriol
Calcitriol - administration & dosage
Calcitriol - analogs & derivatives
Dermatologic Agents - administration & dosage
Double-Blind Method
Drug Combinations
epidermal proliferation and differentiation
Epithelium - metabolism
Epithelium - pathology
human beta defensin-2
Humans
immunohistochemistry
Psoriasis - drug therapy
Psoriasis - metabolism
Psoriasis - pathology
T-lymphocytes
Treatment Outcome
Young Adult
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Summary:The combination of calcipotriol (Cp) and topical corticosteroids increases efficacy and reduces side effects as compared to monotherapies. Previous studies suggest that such combinations may have an added value with respect to reduction of T-cell subsets. A two-compound product consisting of Cp and betamethasone dipropionate (BD) has become available for the treatment of psoriasis and is clinically superior to both monotherapies. No immunohistochemical data are available on the in vivo effects of the two-compound formulation versus monotherapy with respect to the three key processes in psoriasis pathogenesis: epidermal proliferation, epidermal differentiation and inflammation. Therefore, 18 patients were treated with the two-compound product, Cp monotherapy or BD monotherapy for 6 weeks and biopsies were taken before and after 4 and 6 weeks of treatment. These biopsies were stained immunohistochemically and analysed (semi)quantitatively. All treatments decreased the number of Ki-67+ cells and increased the keratin 15+ staining. A more pronounced reduction of epidermal and dermal T-cell markers and human beta defensin-2 was seen following combination treatment, compared with both monotherapies. In conclusion, the investigated markers of the skin immune system and epidermal proliferation indicated an added value of the two-compound product over both monotherapies.
ISSN:0954-6634
1471-1753
DOI:10.3109/09546630903214175