Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar

Abstract This study compared the efficacy of nimesulide and meloxicam in the control of pain, swelling and trismus, following the extraction of impacted inferior third molars. Twenty patients with two impacted inferior third molars, in similar positions, were selected. The patients were designated r...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2010-06, Vol.39 (6), p.580-584
Main Authors: De Menezes, S.A.F, Cury, P.R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cross-Over Studies
Cyclooxygenase Inhibitors - therapeutic use
Dentistry
Diseases of striated muscles. Neuromuscular diseases
edema
Edema - prevention & control
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Humans
Male
Medical sciences
Molar, Third - surgery
Neurology
Non tumoral diseases
non-steroidal anti-inflammatory drugs
Otorhinolaryngology. Stomatology
pain
Pain Measurement
Pain, Postoperative - prevention & control
Pharmacology. Drug treatments
Sulfonamides - therapeutic use
Surgery
Thiazines - therapeutic use
Thiazoles - therapeutic use
Tooth Extraction
Tooth, Impacted - surgery
trismus
Trismus - prevention & control
Young Adult
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Summary:Abstract This study compared the efficacy of nimesulide and meloxicam in the control of pain, swelling and trismus, following the extraction of impacted inferior third molars. Twenty patients with two impacted inferior third molars, in similar positions, were selected. The patients were designated randomly to the meloxicam group (MEL: 7.5 mg twice a day for 5 days) or the nimesulide group (NIM: 100 mg for 5 days). Following the extractions, swelling was more pronounced in the MEL group than in the NIM group ( P ≤ 0.001). There were no significant differences in pain intensity between the treatment groups ( P > 0.05). At the 72-h evaluation, reduction was significantly larger in mouth opening in the MEL group compared with the NIM group ( P < 0.05). In conclusion, pain control was similar in both treatment groups. NIM was more effective than MEL in the control of swelling and trismus following the extraction of impacted lower third molars.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2010.03.012