Spectrophotometric determination of gabapentin in pharmaceutical formulations using ninhydrin and π-acceptors

Simple, rapid and sensitive spectrophotometric procedures are developed for the analysis of gabapentin in pure form as well as in their pharmaceutical formulations. The methods are based on the reaction of gabapentin as n-electron donor with ninhydrin and pi-acceptors namely, 2,3,5,6-tetrachloro-1,4...

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Bibliographic Details
Published in:	European journal of medicinal chemistry 2010-07, Vol.45 (7), p.2761-2767
Main Authors:	Siddiqui, Farhan Ahmed, Arayne, M. Saeed, Sultana, Najma, Qureshi, Faiza, Mirza, Agha Zeeshan, Zuberi, M. Hashim, Bahadur, Saima Sher, Afridi, Nawab Sher, Shamshad, Hina, Rehman, Nadia
Format:	Article
Language:	eng
Subjects:	Amines - analysis Amines - chemistry Analysis Biological and medical sciences Chemistry, Pharmaceutical Cyclohexanecarboxylic Acids - analysis Cyclohexanecarboxylic Acids - chemistry Gabapentin gamma-Aminobutyric Acid - analysis gamma-Aminobutyric Acid - chemistry General pharmacology Hydrocarbons, Aromatic - chemistry Indicators and Reagents - chemistry Kinetics Limit of Detection Linear Models Magnetic Resonance Spectroscopy Medical sciences Ninhydrin - chemistry Ninhydrin and charge transfer complex Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Pi-acceptor Spectrophotometric determination Spectrophotometry - methods Thermodynamics
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Summary:	Simple, rapid and sensitive spectrophotometric procedures are developed for the analysis of gabapentin in pure form as well as in their pharmaceutical formulations. The methods are based on the reaction of gabapentin as n-electron donor with ninhydrin and pi-acceptors namely, 2,3,5,6-tetrachloro-1,4-benzoquinone, chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tetracyanoethylene and 7,7,8,8-tetracyanoquinodimethane. The obtained complexes were measured at 568, 230, 314, 304, 335 and 439 nm for ninhydrin, chloranil, Chloranilic acid, DDQ, TCNE and TCNQ respectively. The proposed procedures could be successfully applied to the determination of gabepentin with good recovery; percent ranged from 99.3 to 100.7 The association constants and free energy changes using Benesi–Hildebrand plots are also studied. [Display omitted]
ISSN:	0223-5234 1768-3254