Comprehensive serotyping and epidemiology of human adenovirus isolated from the respiratory tract of Korean children over 17 consecutive years (1991-2007)

Among the 53 serotypes of human adenoviruses (HAdVs), identified to date, only a limited number have been associated with human respiratory infections. The epidemiology of each of the serotypes differs depending on the location and/or time of surveillance. This study was performed to elucidate the e...

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Bibliographic Details
Published in:Journal of medical virology 2010-04, Vol.82 (4), p.624-631
Main Authors: Lee, Jina, Choi, Eun Hwa, Lee, Hoan Jong
Format: Article
Language:English
Subjects:
Adenovirus Infections, Human - epidemiology
Adenovirus Infections, Human - virology
adenovirus outbreak
adenovirus types
Adenoviruses, Human - classification
Adenoviruses, Human - isolation & purification
Biological and medical sciences
Capsid Proteins - genetics
Child
Child, Preschool
Disease Outbreaks
Epidemiology
Fundamental and applied biological sciences. Psychology
Genotype
Human adenovirus
Human viral diseases
Humans
Infectious diseases
Korea - epidemiology
Medical sciences
Microbiology
molecular epidemiology
multiplex PCR
Nasal Cavity - virology
Neutralization Tests
Polymerase Chain Reaction
Prevalence
Respiratory Tract Diseases - epidemiology
Respiratory Tract Diseases - virology
Sequence Analysis, DNA
Serotyping
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Virology
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Summary:Among the 53 serotypes of human adenoviruses (HAdVs), identified to date, only a limited number have been associated with human respiratory infections. The epidemiology of each of the serotypes differs depending on the location and/or time of surveillance. This study was performed to elucidate the epidemiology of HAdV respiratory infections by comprehensive serotyping of the HAdVs isolated from the respiratory tract of Korean children. HAdVs isolated from respiratory specimens of Korean children over 17 consecutive years (1991–2007) were typed by the neutralization test or molecular methods, including two‐sets of multiplex PCR assays, and/or sequence analysis of the hexon gene. From January 1991 through December 2007, a total of 741 isolates were obtained from nasal aspirates of children hospitalized or requiring medical treatment in the emergency room. All isolates were type‐determined successfully and 13 different serotypes were identified, which included HAdV serotypes 1–8, 11, 19, 34, 37, and 41. HAdV‐3 (n = 285, 37.7%) and HAdV‐7 (n = 181, 23.9%) were the predominant serotypes; HAdV‐8, ‐11, ‐19, ‐34, ‐37, and ‐41 were not usually associated with respiratory diseases. HAdV‐3 was present both during outbreaks and in sporadic cases. HAdV‐7 emerged in a very large outbreak, followed by smaller outbreaks. HAdV‐1, ‐2, ‐4, ‐5, and ‐6 were isolated sporadically throughout the study period. In conclusion, a total of 13 different serotypes of HAdV were detected among Korean children with respiratory tract infections. HAdV‐3 and HAdV‐7 were the most common serotypes, and they were associated with HAdV outbreaks. J. Med. Virol. 82:624–631, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21701