Hepcidin treatment in Hfe−/− mice diminishes plasma iron without affecting erythropoiesis

Eur J Clin Invest 2010; 40 (6): 511–517 Background  Iron is essential for mammalian metabolism and its cellular concentration is controlled by regulating its acquisition and storage. Haemochromatosis is a condition involving iron overload that is characterised by increased duodenal iron absorption a...

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Published in:European journal of clinical investigation 2010-06, Vol.40 (6), p.511-517
Main Authors: Morán-Jiménez, María-Josefa, Méndez, Manuel, Santiago, Begoña, Rodríguez-García, María-Elena, Moreno-Carralero, María-Isabel, Sánchez-Lucío, Ana-Cristina, Grau, Montserrat, Enríquez-de-Salamanca, Rafael
Format: Article
Language:English
Subjects:
Animals
Antimicrobial Cationic Peptides - administration & dosage
Blotting, Western
Erythropoiesis - drug effects
Erythropoietin
Erythropoietin - analysis
ferroportin
Flow Cytometry
Hematocrit
Hemochromatosis - drug therapy
Hemoglobins - analysis
Hepcidins
Iron - metabolism
Liver - metabolism
Mice
Mice, Knockout
transferrin
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Summary:Eur J Clin Invest 2010; 40 (6): 511–517 Background  Iron is essential for mammalian metabolism and its cellular concentration is controlled by regulating its acquisition and storage. Haemochromatosis is a condition involving iron overload that is characterised by increased duodenal iron absorption and a progressive accumulation of iron in vital organs. Hepcidin is the main hormone that regulates iron homoestasis and it is secreted by the liver. Materials and methods  We have studied how extended hepcidin administration affects the iron load status, plasma and tissue iron concentration, erythropoiesis and the expression of proteins involved on iron homeostasis in haemochromatotic (Hfe−/−) and wild‐type mice. Results  Hepcidin reverted the high plasma iron concentrations in Hfe−/− mice to normal values. The high concentration of hepatic iron was not altered in the liver of these Hfe−/− mice. Hepcidin administration did not disturb erythropoiesis in either Hfe−/− or wild‐type mice and likewise, hepcidin did not modify the expression of any protein analysed in the liver, duodenum or spleen of Hfe−/− and wild‐type mice. These data confirm that hepcidin administration diminishes plasma iron concentrations. Conclusion  Treatment with sustained doses of hepcidin diminishes plasma iron concentrations in Hfe−/− mice.
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2010.02291.x