Repeated exposure to low-level extremely low frequency-modulated microwaves affects cortex-hypothalamus interplay in freely moving rats: EEG study

Purpose: To compare the effects of repeated exposure to extremely low frequency-modulated microwaves (ELF-MW) on cortical and hypothalamic electroencephalograms (EEG). Materials and methods: In 10 freely moving rats with carbon electrodes implanted into the cortex and dorsomedial hypothalamus, avera...

Full description

Saved in:
Bibliographic Details
Published in:International journal of radiation biology 2010-05, Vol.86 (5), p.376-383
Main Authors: Vorobyov, Vasily, Jana, Branka, Peši, Vesna, Proli, Zlatko
Format: Article
Language:English
Subjects:
Animals
Carbon - chemistry
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Cerebral Cortex - radiation effects
cortex
Dose-Response Relationship, Radiation
Electrodes
Electroencephalography
ELF-modulated microwaves
Environmental Exposure - adverse effects
frequency spectra
hypothalamus
Hypothalamus - metabolism
Hypothalamus - pathology
Hypothalamus - radiation effects
Microwaves - adverse effects
Movement
Rats
Rats, Wistar
Space life sciences
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To compare the effects of repeated exposure to extremely low frequency-modulated microwaves (ELF-MW) on cortical and hypothalamic electroencephalograms (EEG). Materials and methods: In 10 freely moving rats with carbon electrodes implanted into the cortex and dorsomedial hypothalamus, averaged frequency spectra (0.5-30 Hz) of the EEG were studied for five consecutive days either under sham exposures (five rats) or under mixed sham/MW-exposures (five rats). The rats were exposed to ELF-MW (915 MHz, 20-ms pulse duration, ∼0.3 mW/cm2, 4 Hz) intermittently (1-min 'On', 1-min 'Off') for 10 min (specific absorption rate, SAR, ∼0.7 mW/g on average) several times per day, with 10-min pre- and post-exposure periods. Results: In baseline EEG, the activities of 3.2-6.0 Hz and 17.8-30.5 Hz dominated in the cortex and of 6.0-17.8 Hz in the hypothalamus. This cortical-hypothalamic imbalance was relatively stable at sham-exposures and insensitive to ELF-MW in all frequency ranges but one. ELF-MW increased the beta2 (17.8-30.5 Hz) level in the hypothalamus to a greater extent than in the cortex, causing significant diminishing of the initial EEG bias between them. Moreover, a cumulative phenomenon under repeated exposures to ELF-MW was revealed. Conclusions: These results are in line with evidence that repeated low-level exposure to ELF-MW affects brain functioning and provide an additional approach when analysing underlying mechanisms.
ISSN:0955-3002
1362-3095
DOI:10.3109/09553000903567938