The Antimicrobial Peptide DEFB1 Is Associated with Caries

Genetics is an important component in the determination of individual susceptibility to caries and periodontal diseases. Since beta defensin 1 (DEFB1) localizes in the oral cavity, we tested if variation in DEFB1 is associated with caries and periodontitis. We analyzed 3 single-nucleotide polymorphi...

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Bibliographic Details
Published in:Journal of dental research 2010-06, Vol.89 (6), p.631-636
Main Authors: Ozturk, A., Famili, P., Vieira, A.R.
Format: Article
Language:English
Subjects:
Adenine
Adolescent
Adult
Aged
Aged, 80 and over
Aggressive Periodontitis - genetics
Alleles
Antimicrobial Cationic Peptides - genetics
beta-Defensins - genetics
Biological and medical sciences
Cytosine
Dental Caries - genetics
Dental Caries Susceptibility - genetics
Dentistry
Disease Progression
DMF Index
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Genetic Markers - genetics
Genetic Variation - genetics
Guanine
Haplotypes
Humans
Linkage Disequilibrium - genetics
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Periodontitis - genetics
Pilot Projects
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
Young Adult
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Summary:Genetics is an important component in the determination of individual susceptibility to caries and periodontal diseases. Since beta defensin 1 (DEFB1) localizes in the oral cavity, we tested if variation in DEFB1 is associated with caries and periodontitis. We analyzed 3 single-nucleotide polymorphisms in DEFB1 in DNA samples from unrelated individuals. Carrying a copy of the variant allele of the DEFB1 marker rs11362 (G-20A) increased the DMFT and DMFS scores more than five-fold. Also, carrying a copy of the variant allele of the DEFB1 marker rs179946 (G-52A) correlated with low DMFT scores. We found a high-caries-experience haplotype (GCA), which increased DMFT scores two-fold, and a low- caries-experience haplotype (ACG), which decreased DMFT scores two-fold, in the DEFB1 promoter. No association between DEFB1 genetic markers and periodontal disease was found. Our results suggest that functional polymorphisms of DEFB1 are potential markers for caries.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034510364491