Clinical relevance of persistently elevated circulating cytokines (tumor necrosis factor α and interleukin‐6) in the long‐term followup of patients with giant cell arteritis

Objective To assess the clinical relevance of increased circulating cytokines in patients with giant cell arteritis (GCA) after long‐term followup. Methods We performed a cross‐sectional evaluation of 54 patients with biopsy‐proven GCA prospectively followed for a median of 5.4 years (range 4–10.5 y...

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Published in:Arthritis care & research (2010) 2010-06, Vol.62 (6), p.835-841
Main Authors: García‐Martínez, Ana, Hernández‐Rodríguez, José, Espígol‐Frigolé, Georgina, Prieto‐González, Sergio, Butjosa, Montserrat, Segarra, Marta, Lozano, Ester, Cid, Maria C.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Giant Cell Arteritis - blood
Giant Cell Arteritis - diagnosis
Humans
Interleukin-6 - blood
Male
Middle Aged
Prospective Studies
Recurrence
Time Factors
Tumor Necrosis Factor-alpha - blood
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Summary:Objective To assess the clinical relevance of increased circulating cytokines in patients with giant cell arteritis (GCA) after long‐term followup. Methods We performed a cross‐sectional evaluation of 54 patients with biopsy‐proven GCA prospectively followed for a median of 5.4 years (range 4–10.5 years). GCA‐related complications, vascular events, relapses, current prednisone dose, time required to achieve a maintenance prednisone dosage
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.20043