A novel vasopressin peptide lowers blood pressure through decreases in cardiac output

The changes in blood pressure, cardiac output, and total peripheral conductance evoked by the novel hypotensive arginine vasopressin (AVP) - like peptide, d(CH 2 ) 5 [D-Tyr(Et) 2 ,Arg 3 ,Val 4 ,Arg 7 ,Eda 9 ]AVP (HYPO-AVP), were recorded in conscious unrestrained Sprague–Dawley rats implanted with r...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2003-05, Vol.81 (5), p.497-501
Main Authors: Yu, Ming, Ghosh, Mahua, McNeill, J Robert
Format: Article
Language:English
Subjects:
Animals
Antihypertensive agents
Antihypertensive Agents - pharmacology
Arginine Vasopressin - analogs & derivatives
Arginine Vasopressin - pharmacology
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Cardiac Output - drug effects
Cardiovascular system
Dose-Response Relationship, Drug
Heart failure
Male
Medical sciences
Peptides
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Vascular Resistance - drug effects
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Summary:The changes in blood pressure, cardiac output, and total peripheral conductance evoked by the novel hypotensive arginine vasopressin (AVP) - like peptide, d(CH 2 ) 5 [D-Tyr(Et) 2 ,Arg 3 ,Val 4 ,Arg 7 ,Eda 9 ]AVP (HYPO-AVP), were recorded in conscious unrestrained Sprague–Dawley rats implanted with radiotelemetry pressure transducers and ultrasonic transit-time flowprobes. Intravenous infusions of 0.6, 1.0, 2.0, and 4.0 μg·kg –1 ·min –1 of HYPO-AVP evoked dose-related decreases in blood pressure. At the lowest dose of 0.6 μg·kg –1 ·min –1 , the fall in blood pressure was associated with a small but significant increase in total peripheral conductance. Cardiac output was unchanged. In contrast, at the three higher doses of 1.0, 2.0, and 4.0 μg·kg –1 ·min –1 , the fall in blood pressure was related to a dramatic fall in cardiac output. Indeed, total peripheral conductance decreased, preventing blood pressure from falling further. These hemo dynamic findings should help to direct future research into the mechanism of the putative hypotensive property of vaso pressin, a property that attenuates the well established blood pressure elevating actions of the peptide.Key words: vasopressin, blood pressure, cardiac output, total peripheral resistance, hypotensive peptide.
ISSN:0008-4212
1205-7541
DOI:10.1139/y03-054