Protective effects of taurine on human hair follicle grown in vitro

Taurine is a naturally occurring beta-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown in vitro to recapitulate most of the char...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cosmetic science 2006-08, Vol.28 (4), p.289-298
Main Authors: Collin, C., Gautier, B., Gaillard, O., Hallegot, P., Chabane, S., Bastien, P., Peyron, M., Bouleau, M., Thibaut, S., Pruche, F., Duranton, A., Bernard, B. A.
Format: Article
Language:English
Subjects:
Applied sciences
Chemical industry and chemicals
Cosmetics, toiletries
Exact sciences and technology
in vitro hair growth
taurine
transforming growth factor-β1
Washing products. Cosmetics and toiletries. Perfumes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Taurine is a naturally occurring beta-amino acid produced by methionine and cysteine metabolism. It is involved in a variety of physiological functions, including immunomodulatory and antifibrotic. Taking advantage of the ability of human hair follicle grown in vitro to recapitulate most of the characteristic features of normal hair follicle in vivo, we studied (i) taurine uptake by isolated human hair follicles; (ii) its effects on hair growth and survival rate; and (iii) its protective potential against transforming growth factor (TGF)-beta1, an inhibitor of in vitro hair growth and a master switch of fibrotic program. We showed that taurine was taken up by the connective tissue sheath, proximal outer root sheath and hair bulb, promoted hair survival in vitro and prevented TGF-beta1-induced deleterious effects on hair follicle.
ISSN:0142-5463
1468-2494
DOI:10.1111/j.1467-2494.2006.00334.x