Relationship between radiographic grading of osteoarthritis and serum beta-2 microglobulin

Background Beta-2 microglobulin (B2M) has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. Whether it has a catabolic role in osteoarthritis (OA) remains unclear. Aims To evaluate a possible associa...

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Bibliographic Details
Published in:Irish journal of medical science 2009-06, Vol.178 (2), p.151-154
Main Authors: Melikoglu, M. A., Yildirim, K., Senel, K.
Format: Article
Language:English
Subjects:
Analysis of Variance
beta 2-Microglobulin - blood
Biomarkers
Blood Sedimentation
C-Reactive Protein
Case-Control Studies
Family Medicine
Female
General Practice
Humans
Inflammation - blood
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Osteoarthritis, Knee - blood
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - physiopathology
Radiography
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Summary:Background Beta-2 microglobulin (B2M) has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. Whether it has a catabolic role in osteoarthritis (OA) remains unclear. Aims To evaluate a possible association between serum B2M and radiographic grading of OA. Methods A total of 115 patients with knee OA and 30 controls were divided into subgroups according to Kellgren–Lawrence grading score and their erythrocyte sedimentation rate, C-reactive protein and serum B2M were assessed. Results B2M levels of patients were significantly higher than the controls ( P  
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-008-0219-y